Mrc2 |
17534 |
Knockout |
Delayed re-epithelialization; altered stiffness of the scar tissue; no difference in total collagen content of the wounds |
Mus musculus |
Mstn |
17700 |
Knockout |
Delayed wound healing; delayed epidermal reepithelialization and dermal contraction |
Mus musculus |
Pou2f3 |
18988 |
Knockout |
Various effects on differentiation of epidermal keratinocytes during normal development and wound healing |
Mus musculus |
Msx2 |
17702 |
Knockout |
Accelerated wound closure and re-epithelialization; earlier appearance of keratin markers for differentiation and an increased level of smooth muscle actin and tenascin in the granulation tissue |
Mus musculus |
Myb |
17863 |
Knockout |
Heterozygous c-myb deficiency has a functional effect on wound repair; collagen type I levels and transforming growth factor-beta1 expression are elevated |
Mus musculus |
Myc |
17869 |
Knockout |
Impaired wound healing |
Mus musculus |
Myd88 |
17874 |
Knockout |
Delayed wound healing; delayed contraction; decreased and delayed granulation tissue formation; reduced new blood vessel density |
Mus musculus |
Ncoa3 |
17979 |
Knockout |
Delayed wound healing |
Mus musculus |
Ncoa6 |
56406 |
Knockout |
Spontaneous natural wounds healing defects |
Mus musculus |
Nf1 |
18015 |
Knockout |
Abnormal pattern and amount of collagen-rich granulation bed tissue; skin wound fibroblasts proliferated past the normal wound maturation phase |
Mus musculus |
Nfe2l2 |
18024 |
Knockout |
Prolonged inflammation in the late phase of repair; reduced expression of various key players in the early phase; |
Mus musculus |
Nfic |
18029 |
Knockout |
Accelerated wound closure; faster inflammatory stage; increased expression of PDGFA and PDGF-receptor alpha; reduced differentiation of fibroblasts to myofibroblasts |
Mus musculus |
Nid1 |
18073 |
Knockout |
hyperproliferation of the newly formed epidermis with a delay in differentiation at day 10 post injury; considerable alpha-smooth muscle actin staining in the dermis of wounds |
Mus musculus |
Nlrp3 |
216799 |
Knockout |
Delayed re-epithelialization, granulation tissue formation, and angiogenesis |
Mus musculus |
Nos1 |
18125 |
Knockout |
Delayed wound closure |
Mus musculus |
Nos2 |
18126 |
Knockout |
Delayed wound closure |
Mus musculus |
Nos3 |
18127 |
Knockout |
Delayed wound closure |
Mus musculus |
Npy2r |
18167 |
Knockout |
Delayed wound closure with reduced neovascularization |
Mus musculus |
Nr3c1 |
14815 |
Mutation |
Enlarged granulation tissue with a high fibroblast density; late wounds appeared normal; enhanced ability of fibroblasts to contract collagen |
Mus musculus |
Nr3c1 |
14815 |
Overexpression |
Delayed wound healing; delayed re-epithelialization and formation of granulation tissue; reduced recruitment of granulocytes and macrophages; TGF-β1 and Kgf expression was repressed whereas TGF-β3 was up-regulated |
Mus musculus |
Nr4a1 |
15370 |
Knockout; overexpression |
Delayed wound healing in a dominant negative mutant |
Mus musculus |
Ogfr |
72075 |
Overexpression |
Delayed wound healing |
Mus musculus |
Oprd1 |
18386 |
Knockout |
Delayed wound healing; severe epidermal hypertrophy at the wound margin |
Mus musculus |
P2ry2 |
18442 |
Knockout |
Increased wound size at day 14 post-wounding; reduction in the expression of Ki67, VEGF, collagen I, fibronectin and α-SMA |
Mus musculus |
Panx1 |
55991 |
Knockout |
Delayed wound healing |
Mus musculus |
Pear1 |
73182 |
Knockout |
Accelerated wound closure |
Mus musculus |
Perp |
64058 |
Knockout |
Delayed wound healing |
Mus musculus |
Pgf |
18654 |
Knockout |
Impaired angiogenesis, plasma extravasation and collateral growth |
Mus musculus |
Pik3cg |
30955 |
Mutation |
Delayed resolution of inflammation in wound healing; increased proliferation and decreased apoptosis |
Mus musculus |
Pkd1 |
18763 |
Knockout |
Delayed wound re-epithelialization; reduced proliferation and migration of keratinocytes at the wound edge |
Mus musculus |
Plaur |
18793 |
Knockout |
Delayed wound healing |
Mus musculus |
Plec |
18810 |
Knockout |
Reduced leukocyte infiltration |
Mus musculus |
Plg |
18815 |
Knockout |
Impaired wound healing |
Mus musculus |
Postn |
50706 |
Knockout |
Delayed wound healing (rescued by direct administration of exogenous periostin) |
Mus musculus |
Pou3f1 |
18991 |
Knockout |
Various effects on differentiation of epidermal keratinocytes during normal development and wound healing |
Mus musculus |
Ppara |
19013 |
Mutation |
Modulation of early inflammation phase |
Mus musculus |
Ppard |
19015 |
Mutation |
Impaired adhesion and migration properties |
Mus musculus |
Pparg |
19016 |
Knockout |
Impaired wound healing with reduced collagen deposition, angiogenesis and granulation formation |
Mus musculus |
Ppp1r15a |
17872 |
Knockout |
Accelerated wound healing; reduced amounts of myosin IIA in migrating macrophages and myofibroblasts |
Mus musculus |
Prdx6 |
11758 |
Knockout |
Damaged endothelial cells with an enhanced rate of apoptosis; hemorrhage in the granulation tissue |
Mus musculus |
Prkca |
18750 |
Knockout |
Delayed granulation tissue deposition; failure to upregulate collagen and other ECM components |
Mus musculus |
Prkce |
18754 |
Knockout |
Delayed wound closure and a reduction in myofibroblasts |
Mus musculus |
Prkch |
18755 |
Knockout |
Delayed wound healing, particularly re-epithelialization |
Mus musculus |
Pten |
19211 |
Knockout |
Various effects indicating the importance of mTOR |
Mus musculus |
Ptger3 |
19218 |
Knockout |
Delayed wound closure and re-epithelization; inhibited angiogenesis; reduction in immunoreactive vascular endothelial growth factor (VEGF) in granulation tissues |
Mus musculus |
Ptgs1 |
19224 |
Knockout |
Reduced breaking strength; enhanced angiogenesis; reduced macrophages and myofibroblasts at day 12 |
Mus musculus |
Ptgs2 |
19225 |
Knockout |
Reduced breaking strength; enhanced angiogenesis; reduced macrophages and myofibroblasts at day 12 |
Mus musculus |
Ptk2 |
14083 |
Knockout |
Delayed wound healing; decreased dermal thickness and collagen density |
Mus musculus |
Ptk2b |
19229 |
Knockout |
Delayed wound closure |
Mus musculus |
Ptk7 |
71461 |
Knockout |
Defective wound repair |
Mus musculus |
Rac1 |
19353 |
Knockout |
Delayed wound closure; reduced collagen production and myofibroblast formation |
Mus musculus |
Rac2 |
19354 |
Knockout |
Reduced wound-related lipid peroxidation |
Mus musculus |
Raf1 |
110157 |
Knockout |
Delayed wound healing |
Mus musculus |
Ramp1 |
51801 |
Knockout |
Suppressed wound healing and wound-induced angiogenesis; reduced expression of vascular endothelial growth factor (VEGF)-A |
Mus musculus |
Reck |
631094 |
Knockout |
Improved wound healing |
Mus musculus |
Ripk3 |
56532 |
Knockout |
Delayed wound healing |
Mus musculus |
S100a9 |
20202 |
Knockout |
Diminished recruitment of granulocytes into the granulation tissue |
Mus musculus |
Scrib |
105782 |
Knockout |
Defective wound repair |
Mus musculus |
Sdc1 |
20969 |
Knockout |
Prolonged hypoplasia; delayed cell proliferation and reduced localization of alpha9 integrin in the epidermis |
Mus musculus |
Sdc4 |
20971 |
Knockout |
Delayed wound healing and impaired angiogenesis in the granulation tissue |
Mus musculus |
Sele |
20339 |
Double Knockout |
Reduced recruitment of inflammatory cells and impaired wound closure in mice deficient in both P- and E-selectins |
Mus musculus |
Sell |
20343 |
Knockout |
Delayed wound healing |
Mus musculus |
Selp |
20344 |
Double Knockout |
Reduced recruitment of inflammatory cells and impaired wound closure in mice deficient in both P- and E-selectins |
Mus musculus |
Sept4 |
18952 |
Knockout |
Improvement in wound healing and regeneration of hair follicles |
Mus musculus |
Serpine1 |
18787 |
Knockout |
Accelerated wound closure |
Mus musculus |
Serpinf2 |
18816 |
Knockout |
Accelerated wound closure; increased angiogenesis |
Mus musculus |
Spi1 |
20375 |
Knockout |
Accelerated wound healing with reduced fibrosis; incapacity to raise the standard inflammatory response, due to a lack of macrophages and functioning neutrophils |
Mus musculus |
Siah2 |
20439 |
Knockout |
Delayed wound healing; delayed induction of myofibroblast infiltration and reduced collagen deposition; delayed angiogenesis and reduced macrophage infiltration into the wounds |
Mus musculus |
Slc11a1 |
18173 |
Knockout |
Delayed wound healing |
Mus musculus |
Slc6a6 |
21366 |
Knockout |
Delayed wound closure in 12-mo mice; no effect in 5-mo mice |
Mus musculus |
Slpi |
20568 |
Knockout |
Impaired wound healing with increased inflammation and elastase activity |
Mus musculus |
Smad2 |
17126 |
Overexpression |
Delayed wound healing; a defect in basal keratinocyte migration |
Mus musculus |
Smad3 |
17127 |
Knockout |
Accelerated dorsal wound healing; ear wounds are enlarged resulting from changes in extracellular matrix molecules |
Mus musculus |
Smad4 |
17128 |
Knockout |
Delayed wound closure and remodeling; increased angiogenesis and inflammation |
Mus musculus |
Smad7 |
17131 |
Overexpression |
Accelerated re-epithelialization; increase in keratinocyte proliferation; reduced Smad2 activation; increased activation of extracellular signal-regulated kinase (Erk) |
Mus musculus |
Snai2 |
20583 |
Knockout |
Reduced re-epithelialization; increased expression of the Slug target genes keratin 8 and E-cadherin at wound margins; 40% of mice developed non-healing cutaneous ulcers in response to chronic UVR |
Mus musculus |
Socs3 |
12702 |
Overexpression |
Impaired wound healing; atrophied wound-margin epithelia and augmented response of keratinocytes; a prolonged persistence of neutrophils and macrophages; elevated levels of TGF-beta1 |
Mus musculus |
Sod1 |
545845 |
Knockout |
Delayed wound healing |
Mus musculus |
Sorbs3 |
20410 |
Knockout |
Delay in wound healing in both back and tail, without affecting the proliferation of keratinocytes |
Mus musculus |
Sparc |
100046740 |
Knockout |
Accelerated wound closure |
Mus musculus |
Sparcl1 |
13602 |
Knockout |
Accelerated wound healing; enhanced macrophage infiltration of wound beds at early time points; earlier appearance of mature extracellular matrix; fibrovascular invasion of polyvinyl alcohol sponges was more robust |
Mus musculus |
Spi1 |
20375 |
knockout |
Scar-free repair; altered growth factor and cytokine profile; cell death is reduced, and dying cells are instead engulfed by stand-in phagocytic fibroblasts |
Mus musculus |
Spp1 |
20750 |
Knockout |
Decreased level of debridement; greater disorganization of matrix; alteration of collagen fibrillogenesis leading to small diameter collagen fibrils; tensile properties of the wounds were unchanged |
Mus musculus |
Stat3 |
20848 |
Knockout |
Compromised wound healing and hair cycle; developed spontaneously occurring ulcers with age |
Mus musculus |
Tcf3 |
21423 |
Overexpression |
Accelerated wound healing and keratinocyte migration |
Mus musculus |
Tert |
21752 |
Overexpression |
Accelerated wound healing |
Mus musculus |
Tgfa |
21802 |
Knockout |
Ear model: delayed re-epithelialization; Head model: no difference in epithelial gap or new granulation tissue |
Mus musculus |
Tgfb1 |
21803 |
Knockout |
Decreased granulation tissue formation, vascularity, collagen deposition, epithelialization and a marked inflammatory infiltrate |
Mus musculus |
Tgfb3 |
21809 |
Protein administration |
Scar-free wound healing in adults |
Mus musculus |
Tgfbr2 |
21813 |
Knockout |
Accelerated wound closure and re-epithelization; reduced collagen deposition and remodeling; reduced extent of wound contraction, and elevated macrophage infiltration |
Mus musculus |
Tgm1 |
21816 |
Knockout |
Delayed wound healing |
Mus musculus |
Thbd |
21824 |
Overexpression |
Delayed wound healing; reduced granulation tissue formation and highly diminished wound angiogenesis |
Mus musculus |
Thbs1 |
21825 |
Overexpression |
Delayed wound healing; reduced granulation tissue formation and highly diminished wound angiogenesis |
Mus musculus |
Thbs2 |
21826 |
Knockout |
Improved wound healing |
Mus musculus |
Thra |
100047427 |
Knockout |
Delayed re-epithelialization and wound closure; impaired keratinocyte proliferation |
Mus musculus |
Thrb |
21834 |
Knockout |
Delayed re-epithelialization and wound closure; impaired keratinocyte proliferation |
Mus musculus |
Thy1 |
21838 |
siRNA treatment |
Impaired wound healing; the level of TGF-β1 at the wound continuously increased |
Mus musculus |
Timp1 |
21857 |
Knockout |
Delayed wound healing with slow migration of keratinocytes over the wound |
Mus musculus |
Tlr2 |
24088 |
Knockout |
Delayed wound healing; decreased numbers of infiltrating macrophages in the dermis and decreased TGF-β and CCL5 mRNA expression |
Mus musculus |
Tlr4 |
21898 |
Knockout |
Delayed wound healing; decreased numbers of infiltrating macrophages in the dermis and decreased TGF-β and CCL5 mRNA expression |
Mus musculus |