Browse all genes (384)


Gene symbol Entrez ID Intervention Effect on wound healing Organism
Tlr9 81897 Knockout Delayed wound healing Mus musculus
Tnf 21926 Knockout Promotion of granulation tissue formation and delayed re-epithelialization Mus musculus
Tnfrsf1a 21937 Knockout Accelerated wound healing; enhanced angiogenesis and collagen content; accelerated re-epithelialization with increased gene expression of TGF-beta1, CTGF, VEGF, Flt-1, and Flk-1 Mus musculus
Tnfsf14 50930 Knockout Impaired wound healing with characteristics of nonchronic and chronic ulcers Mus musculus
Tnxb 81877 Knockout Reduced breaking strength of unwounded skin; after wounding, scars do not progress beyond the mechanical strength of uninjured skin; no obvious differences in the rate of wound closure Mus musculus
Tpm3 236479 Deletion of exon Accelerated wound healing; increased cell migration Mus musculus
Trp53 22059 Mutation Delayed wound closure Mus musculus
Trpc6 22068 Knockout Impaired wound healing Mus musculus
Tsc1 64930 Knockout Accelerated wound healing Mus musculus
Tsk2 109631 Knockout Delayed wound healing Mus musculus
Vangl2 93840 Knockout; Double Knockout Defective wound repair Mus musculus
Vav1 22324 Knockout Delayed wound healing Mus musculus
Vav3 57257 Knockout Delayed wound healing Mus musculus
Vegfa 22339 Overexpression; inhibitor administration Promotion of lymphangiogenesis; systemic blockade of VEGFR-2 prevented lymphatic vessel formation Mus musculus
Vegfa 22339 Overexpression Rapid wound closure Mus musculus
Vegfa 22339 Protein administration Improved wound healing by locally up-regulating growth factors important for tissue repair and by systemically mobilizing bone marrow-derived cells Mus musculus
Vim 22352 Knockout Delayed wound contraction, migration of fibroblasts into the wound site, and appearance of myofibroblasts at the wound site Mus musculus
Vtn 22370 Knockout Delayed wound healing; extensive areas of delayed hemorrhage near the sprouting tips of microvessels between days 7 and 14 Mus musculus
Wfdc1 67866 Knockout Accelerated wound closure; elevated deposition of osteopontin and macrophage recruitment Mus musculus
Vegfa 83785 Overexpression (local plasmid injection) Increased skin flap perfusion; increase in skin flap healing and survival Rattus norvegicus
Adrb1 24925 Antagonist administration Delayed contraction in propranolol- and atenolol-treated animals but not in phentolamine-treated animals; re-epithelialization was decreased only in propranolol-treated animals Rattus norvegicus
Adrb2 24176 Antagonist administration Delayed contraction in propranolol- and atenolol-treated animals but not in phentolamine-treated animals; re-epithelialization was decreased only in propranolol-treated animals Rattus norvegicus
Agt 24179 Protein administration Accelerated wound closure Rattus norvegicus
Ankrd1 27064 Overexpression Increased vascular component in granulation tissue Rattus norvegicus
C3 24232 Protein administration Increased maximal breaking strength; increased fibroblast and collagen deposition; additive hemostatic effect with the C3C5 combination Rattus norvegicus
C5 362119 Protein administration Increased maximal breaking strength; increased fibroblast and collagen deposition; additive hemostatic effect with the C3C5 combination Rattus norvegicus
C5 362119 Protein administration Increased maximal breaking strength; accelerated wound healing; increased vascular permeability, increased inflammatory cell recruitment, subsequent fibroblast migration, and increased collagen deposition Rattus norvegicus
Cfh 155012 Protein administration Accelerated wound closure Rattus norvegicus
Egf 25313 Protein administration Accelerated wound closure; Accelerated epidermal proliferation Rattus norvegicus
Egf 25313 Protein administration Promotion of wound healing Rattus norvegicus
Egf 25313 Overexpression Flap survival was enhanced by 14%, and was accomplished without accessing the arterial inflow of the territory Rattus norvegicus
Egf 25313 Protein administration Accelerated re-repithelialization Rattus norvegicus
Epo 24335 Protein administration, antibody treatment Protein administration: Increased granulation tissue formationr; Receptor or neutralizing antibody administration: inhibited granulation tissue formation Rattus norvegicus
Epor 24336 Protein administration, antibody treatment Protein administration: Increased granulation tissue formationr; Receptor or neutralizing antibody administration: inhibited granulation tissue formation Rattus norvegicus
F2 29251 Peptide administration Accelerated wound closure in both normal and ischemic skin Rattus norvegicus
Fgf10 25443 Protein administration Accelerated re-epithelialization in the meshed skin graft model; more rapid gain in breaking strength of surgical incisions Rattus norvegicus
Fgf2 54250 Antibody treatment Reduced collagen content Rattus norvegicus
Fgf2 54250 Protein administration Increased α-SMA up to day 18 and then caused a decrease Rattus norvegicus
Fgf7 29348 Overexpression (liposomal gene transfer) Increased re-epithelialization; improved dermal regeneration; increased neovascularization Rattus norvegicus
Hgf 24446 Protein administration Accelerated re-epithelialization in diabetic rats; increased expressions of the cell adhesion molecules β1-integrin and the cytoskeleton remodeling protein integrin-linked kinase (ILK) in epidermal cells Rattus norvegicus
Hpse 64537 Protein administration Accelerated wound healing and improved FLAP survival; enhanced wound re-epithelialization and blood vessel maturation Rattus norvegicus
Igf1 24482 Overexpression (liposomal gene transfer) Improved dermal regeneration by an increased collagen deposition and morphology; increased VEGF concentrations and neovascularization Rattus norvegicus
Igf1 24482 Overexpression (in exogenous fibroblasts) More organised granulation tissue formation; increased number of keratinocytes Rattus norvegicus
Itgb2 309684 Antibody treatment Improved flap survival; decreased dermal and anastomotic myeloperoxidase activity Rattus norvegicus
Lama3 307582 Peptide administration Accelerated re-epithelialization; reduced inflammatory cell infiltration; enhanced fibroblast proliferation Rattus norvegicus
Lep 25608 Protein administration Increased granulation tissue; improved angiogenesis; better flap survival Rattus norvegicus
Lox 24914 Gene activated matrix Enhanced mechanical strength of the wound site Rattus norvegicus
Mmp8 63849 Overexpression Impaired wound healing by decreased collagen deposition and breaking strength; decreased number of neutrophils Rattus norvegicus
Ngf 310738 Protein administration Accelerated wound healing, re-epithelialization, formation of granulation tissue, and collagen production Rattus norvegicus
Pdgfb 24628 Protein administration Accelerated wound healing; Accelerated degradation of the polymer and enhanced formation of new granulation tissue as early as day 3 Rattus norvegicus
Proc 25268 Protein administration Enhanced wound healing Rattus norvegicus
Adm 25026 Protein administration Accelerated wound closure Rattus norvegicus
Tgfb1 59086 Antibody treatment, protein administration Neutralising TGF-beta 1: reduced the monocyte and macrophage profile, neovascularisation, fibronectin, collagen III and collagen I deposition in the early stages of wound healing; improved the architecture of the neodermis to resemble that of normal dermis and reduced scarring; effect was stronger when comined with TG-beta 2 neutralization; Protein treatment: more extracellular matrix deposition in the early stages of wound healing but did not differ from control wounds in the final quality of scarring Rattus norvegicus
Tgfb1 59086 Protein administration Accelerated wound healing; Increased wound breaking strength; increased influx of mononuclear cells and fibroblasts; increases in collagen deposition Rattus norvegicus
Tgfb2 81809 Antibody treatment, protein administration Neutralising TGF-beta 2 alone had no effect; combined with TGF-beta 1, it reduced the monocyte and macrophage profile, neovascularisation, fibronectin, collagen III and collagen I deposition in the early stages of wound healing; markedly improved the architecture of the neodermis to resemble that of normal dermis and reduced scarring; by contrast, wounds treated with either TGF-beta 1 or with TGF-beta 2 had more extracellular matrix deposition in the early stages of wound healing but did not differ from control wounds in the final quality of scarring Rattus norvegicus
Tgfb3 25717 Protein administration Reduced the monocyte and macrophage profile, fibronectin, collagen I and collagen III deposition in the early stages of wound healing and improved the architecture of the neodermis and reduced scarring Rattus norvegicus
Tgfbr2 81810 Overexpression Inhibited inflammatory reaction with reduced inflammatory cells; reduced scarring area Rattus norvegicus
Tmsb4x 81814 protein dimer administration Accelerated wound healing Rattus norvegicus
APCS 396921 local depletion by ionized agarose gel Accelerated wound healing Sus scrofa domesticus
CALR 100381266 Protein administration Accelerated wound healing; increase in epithelial migration and granulation tissue formation; marked proliferation of basal keratinocytes and dermal fibroblasts; dense cellularity of the dermis with notably increased numbers of macrophages and well-organized collagen fibril deposition Sus scrofa domesticus
EGF 397083 Protein administration Accelerated re-epithelialization Sus scrofa domesticus
EGF 397083 Protein administration Accelerated wound closure; improved wound healing quality in terms of number of arranged microvasculature, fibroblast migration and proliferation, collagen deposition and evolution of the inflammatory response Sus scrofa domesticus
EGF 397083 Overexpression (Adenoviral transfection) Promotion of resurfacing; enhanced wound maturity Sus scrofa domesticus
ERBB3 100126862 Overexpression (Adenoviral transfection) Promotion of resurfacing; enhanced wound maturity Sus scrofa domesticus
FGF2 397643 Protein administration Better reconstruction quality in terms of hardness and the function of the stratum corneum Sus scrofa domesticus
GJA1 397259 Peptide administration Decreased scar progenitor tissue area; promoted restoration of dermal histoarchitecture and mechanical strength; reduction in inflammatory neutrophil infiltration Sus scrofa domesticus
HSP90AA1 397028 Peptide administration Accelerated wound healing; accelerated re-epithelialization Sus scrofa domesticus
LTF 397649 Protein administration Accelerated re-epithelialization; increased keratinocyte proliferation and migration Sus scrofa domesticus
NRG3 100158106 Overexpression (Adenoviral transfection) Promotion of resurfacing; enhanced wound maturity Sus scrofa domesticus
VTN 397192 Protein administration Accelerated re-epithelialization; improved morphological features such as wound contraction, scar profile, and hair follicle density Sus scrofa domesticus
VEGFA 7422 Overexpression (intramuscular gene transfer) Nonhealing ulcers healed better; improved blood flow with newly visible collateral vessels; adverse consequences were limited to transient ankle or calf edema Homo sapiens
CSF2 1437 Protein administration Elevated number of healed wounds; minor side-effects; none of the treated ulcers recurred after 6 months Homo sapiens
EGF 1950 Protein administration Reduction in ulcer size and a larger number of healed ulcers; failed to enhance re-epithelialization; no side effects Homo sapiens
GJA1 2697 Peptide administration Reduction in ulcer area; accelerated re-epithelialization Homo sapiens
EGF 1950 Protein administration Accelerated epidermal regeneration Homo sapiens
F13A1 2162 Protein administration Improved wound healing; improved granulation tendency; reduction of secretion and bleeding tendency within the ulcer area Homo sapiens
FGF10 2255 Protein administration Accelerated wound healing, with more patients achieving wound closure Homo sapiens
FGF2 2247 Protein administration Improved wound healing; increased fibroblasts and capillaries; more patients achieved > 70% wound closure Homo sapiens
PDGFB 5155 Protein administration Improved wound healing in the feet of diabetics when used in conjunction with standard wound healing practices Homo sapiens
PDGFB 5155 Protein administration After 6 months of topical administration, sufficient granulation tissue developed within the dermal wound; a split-thickness skin graft was successfully performed; wound transformed from a chronic state to a short-term healing state Homo sapiens
PDGFB 5155 Protein administration rhPDGF was more effective than standard therapy in both helping a wound to heal and preventing amputation; the effect was similar to the efficacy estimated from previously published randomized controlled trials Homo sapiens
PDGFB 5155 Protein administration Greater healing response; no toxic effects Homo sapiens
TGFB3 7043 Various Various; Improved quality of scar tissue Homo sapiens
TGFB3 7043 Protein administration Improved total scar scores; less abnormal orientation of collagen fibres in the reticular dermis Homo sapiens

Contact: Vadim E. Fraifeld, MD, PhD
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