Fga |
14161 |
Knockout |
Altered pattern of epithelial cell migration and increased epithelial hyperplasia; granulation tissue failed to adequately close the wound gap, resulting in persistent open wounds or partially covered sinus tracts; reduced tensile strength |
Fgf2 |
14173 |
Knockout |
Delayed wound healing |
Fgfr1 |
14182 |
Knockout |
Delayed wound healing; impaired wound contraction and a delay in re-epithelialization |
Fgfr1op2 |
675026 |
Overexpression |
Accelerated wound closure; limited granulation tissue formation |
Fgfr2 |
14183 |
Knockout |
Delayed reepithelialization; abnormalities in the hair follicles; dermal hyperthickening |
Fgfr2 |
14183 |
Knockout |
Delayed wound healing and re-epithelialization; impaired wound contraction |
Fhl2 |
14200 |
Knockout |
Impaired collagen contraction and cell migration; reduced expression of α-SMA |
Flii |
100044937 |
Knockout; antibody treatment |
Intradermal injection of Flii-neutralizing antibodies to burn wounds improved their healing; Knockout: TGF-beta1 protein and gene expression were reduced while aTGF-beta3 was elevated; decreased anti-α-SMA |
Flna |
192176 |
Knockout |
Delayed wound healing |
Fmod |
14264 |
Knockout |
Delayed wound closure and significantly increased scar size |
Fn1 |
14268 |
Mutation |
Abnormal wound healing |
Fntb |
639541 |
Knockout |
Delayed wound healing |
Foxo1 |
56458 |
Knockout |
Accelerated wound healing with enhanced keratinocyte migration; reduced granulation tissue formation; decreased collagen density; attenuated inflammatory response (only in heterozygous knockout) |
Foxo3 |
56484 |
Knockout |
Accelerated wound healing |
Fpr1 |
14293 |
Double Knockout |
Delayed wound healing in double KO; no effect in single KO |
Fpr2 |
14289 |
Double Knockout |
Delayed wound healing in double KO; no effect in single KO |
Fst |
14313 |
Knockout |
Delayed wound healing; reduced granulation tissue formation; reduction in wound breaking strength; smaller scar area |
Gja1 |
14609 |
Knockout |
Accelerated wound closure |
Gjb3 |
14620 |
Mutation |
Accelerated wound healing |
Gpr39 |
71111 |
Knockout |
Delayed wound healing during the intermediate stage |
Grhl3 |
230824 |
Knockout |
Deficient wound repair and defective skin barrier function |
H2-Eb1 |
14969 |
Knockout |
Impaired wound collagen deposition and breaking strength; diminished mitogen-reactivity of splenic T-cells |
Has1 |
15116 |
Overexpression |
Promotion of dermal regeneration; decreased inflammatory response; recapitulation of fetal extracellular matrix HMW-HA content |
Hbegf |
15200 |
Knockout |
Impaired wound closure |
Hdc |
15186 |
Knockout; overexpression |
Knockout: Delayed wound healing; Overexpression: accelerated wound healing |
Hgf |
15234 |
Overexpression |
Increased granulation tissue with marked vascularization |
Hif1a |
15251 |
Knockout |
Accelerated wound closure and re-epithelialization |
Hif1a |
15251 |
Knockout |
Impaired wound closure and revascularization of ischemic tissue |
Hmmr |
15366 |
Knockout |
Aberrant granulation tissue; defective activation of fibroblast migration/differentiation |
Hmox1 |
15368 |
Knockout; overexpression; inhibitor administration |
Inhibition and knockout: delayed wound closure; Overexpression: accelerated wound closure and improved neovascularization |
Hmox2 |
15369 |
Knockout |
Delayed wound closure; reduced collagen deposition and vessel density |
Hoxa3 |
15400 |
Overexpression |
Acceleration of diabetic wound closure |
Hoxb13 |
15408 |
Knockout; overexpression |
Enhanced wound healing and high levels of hyaluronan; reduced long-term scarring |
Hoxd3 |
15434 |
Overexpression |
Acceleration of diabetic wound closure |
Hpse |
15442 |
Antibody treatment |
Improved wound healing |
Hspb1 |
15507 |
Knockout |
Delayed wound healing; reduced re-epithelialisation and collagen deposition; increased inflammation; augmented neutrophil infiltration in wounds |
Hspg2 |
15530 |
Knockout |
Delayed wound healing and defective angiogenesis |
Icam1 |
15894 |
Knockout |
Delayed wound healing |
Icos |
54167 |
Knockout |
Delayed wound healing, especially at early times; suppressed keratinocyte migration, angiogenesis and granulation tissue formation; diminished T-cell, macrophage and neutrophil infiltration; Marked suppression of cytokine expression in wounds, especially the Th2 cytokines interleukin (IL)-4; IL-6; and IL-10 |
Icosl |
50723 |
Knockout |
Delayed wound healing, especially at early times; suppressed keratinocyte migration, angiogenesis and granulation tissue formation; diminished T-cell, macrophage and neutrophil infiltration; Marked suppression of cytokine expression in wounds, especially the Th2 cytokines interleukin (IL)-4; IL-6; and IL-10 |
Ido1 |
15930 |
Knockout; inhibitor administration |
Accelerated wound healing; Inhibitor administration accelerated wound healing in WT mice |
Ifng |
15978 |
Knockout |
Accelerated wound healing; rapid granulation tissue formation; enhanced angiogenesis |
Igf1 |
16000 |
Overexpression |
Accelerated wound healing; increased proliferation and migration of keratinocytes |
Il10 |
16153 |
Knockout |
Accelerated wound healing; accelerated re-epithelialization and enhanced contraction of the wound tissue |
Il15 |
16168 |
Overexpression |
Accelerated wound healing |
Il1r1 |
16177 |
Knockout |
Improved restoration of normal skin architecture with lower levels of collagen in wounds |
Il1rn |
16181 |
Knockout |
Attenuated collagen deposition and delayed neovascularization; exaggerated neutrophil recruitment with augmented expression of IL-1s, TNF-alpha, and CXC chemokines (MIP-2 and KC) |
Il22 |
50929 |
Knockout |
Defects in the dermal compartment after wounding |
Il33 |
77125 |
Protein administration |
Accelerated wound healing with enhanced re-epithelialization |
Il4 |
16189 |
Double Knockout |
Poor scar histology and increased inflammation |
Il5 |
16191 |
Knockout; overexpression |
IL-5 overexpression vs. knockout: delayed wound healing with impaired re-epithelialization; delay in collagen deposition; increase in inflammatory cell infiltration; altered inflammatory response |
Il6 |
16193 |
Knockout |
Delayed wound healing; minimal epithelial bridge formation; decreased inflammation, and granulation tissue formation |
Il6ra |
16194 |
Knockout; antibody treatment |
Attenuates the delayed wound healing phenotype of IL6 knockout |
Ilk |
621824 |
Knockout |
Delayed wound closure; decrease in cellular proliferation and loss of HGF protein expression |
Inhba |
16323 |
Overexpression |
Enhanced granulation tissue formation; premature induction of fibronectin and tenascin-C; thickening of the epidermis; increased spinous cell layer; disorganized epidermal architecture |
Itch |
16396 |
Knockout |
Accelerated wound healing with a delay in epithelial remodeling |
Itga11 |
319480 |
Knockout |
Reduced granulation tissue formation and impaired wound contraction; dermal fibroblasts are unable to efficiently convert to myofibroblasts, resulting in scar tissue with compromised tensile strength |
Itga3 |
16400 |
Knockout |
Impaired wound healing |
Itga9 |
104099 |
Knockout |
Thinner migrating epithelium; reduction in the number of proliferating epidermal keratinocytes |
Itgam |
16409 |
Knockout |
Delayed wound healing |
Itgb1 |
16412 |
Knockout |
Impaired wound healing |
Itgb2 |
16414 |
Knockout |
Impaired wound healing |
Itgb3 |
16416 |
Knockout |
Accelerated wound healing and re-epithelialization |
Itgb6 |
16420 |
Knockout |
Delayed wound healing; the most significant delay was observed at the stages where granulation tissue deposition was occurring |
Jun |
16476 |
Knockout |
Defects in epidermal wound healing |
Junb |
16477 |
Knockout |
Delayed tissue remodelling; pronounced epidermal hyperproliferation after treatment with the phorbol ester 12-O-decanoyl-phorbol-13-acetate; disturbed differentiation; prolonged inflammation |
Kit |
16590 |
Antibody treatment |
Reduced mast cell accumulation at the edge of healing wounds |
Kl |
16591 |
Knockout |
Delayed wound closure; reduced collagen deposition in the wounds; Phenotypic similarities with aged skin |
Klf10 |
21847 |
Knockout |
Lower wound breaking strength |
Klf10 |
21847 |
Knockout |
Delay in wound closure; impaired wound contraction, granulation tissue formation, collagen synthesis, and reepithelialization |
Klf4 |
16600 |
Knockout |
Delayed wound healing; decreased stem cell-enriched population |
Klf4 |
16600 |
Knockout |
Delayed wound healing; decreased accumulation of Myeloid-derived suppressor cells and fibrocytes |
Klk8 |
259277 |
Knockout |
Delayed wound healing; defective keratinocyte proliferation, differentiation, and migration in the early stages of wound healing |
Krt6a |
16687 |
Knockout |
Delay in re-epithelialization only from the hair follicle; healing of wounds was not impaired |
Krt76 |
77055 |
Knockout |
Impaired wound healing; neonatal skin flaking; hyperpigmentation, inflammation, and death prior to 12 weeks of age |
Lep |
16846 |
Knockout; protein administration; antibody treatment |
Knockout: Delayed wound healing; mild diabetic phenotype; systemically and topically supplemented leptin improved re-epithelialization of wounds in knockout mice; topically supplemented leptin accelerated normal wound-healing |
Lgals1 |
16852 |
Knockout |
Delayed wound healing |
Lgals3bp |
19039 |
Knockout |
Delayed wound healing; reduced collagen expression |
Lgals7 |
16858 |
Knockout |
Reduced reepithelialization potential; defect in cell migration |
Lpp |
210126 |
Knockout |
Reduced embryonic fibroblast migration |
Lsp1 |
16985 |
Knockout |
Accelerated wound healing and re-epithelialization; increased collagen synthesis and angiogenesis |
Lum |
17022 |
Knockout |
Delayed wound healing; increase in inflammatory macrophages; delayed response of the expression of TGF-β1, type I collagen α1 and fibronectin |
Map3k1 |
26401 |
siRNA knockdown |
Delayed wound closure; impaired activation of Jun NH2-terminal kinases, induction of plasminogen activator inhibitor (PAI)-1, and restoration of cell-cell junctions of the wounded epidermis |
Map3k5 |
675366 |
Knockout |
Retardation of wounding-induced hair regrowth |
Map3k7 |
666611 |
Knockout |
Impaired wound healing; decreased collagen deposition, α-SMA and CCN2 expression |
Mapkapk2 |
17164 |
Knockout |
Higher level of acanthosis of the migrating wound keratinocyte layer; higher level of collagen deposition in the granulation tissue |
Med1 |
19014 |
Knockout |
Accelerated wound closure and re-epithelialization |
Met |
17295 |
Knockout |
Keratinocytes were unable to contribute to re-epithelialization; wound closure was slightly attenuated, but occurred exclusively by a few (5%) keratinocytes that had escaped recombination |
Mfap2 |
17150 |
Knockout |
Altered wound healing response |
Mfge8 |
17304 |
Knockout |
Delayed wound healing; reduced myofibroblast and vessel numbers |
Mgat5 |
107895 |
Overexpression |
Accelerated wound healing |
Mif |
100040259 |
Knockout |
Delayed wound healing |
Mir155 |
387173 |
Knockout |
Accelerated wound closure; elevated numbers of macrophages |
Mir21a |
387140 |
Overexpression; antagonist andministration |
Overexpression of miR-21: stronger wound contraction; antagomiR administration: delay of wound closure with impaired collagen deposition |
Mmp13 |
17386 |
Knockout |
Delayed wound healing |
Mmp1a |
83995 |
Mutation |
Delayed wound healing (in mice expressing the human gene in the epidermis) |
Mmp3 |
17392 |
Knockout |
Wounds failed to contract and healed more slowly |
Mmp8 |
17394 |
Knockout |
Impaired wound healing |
Mmp9 |
17395 |
Knockout |
Delayed wound healing; defect in keratinocyte migration |
Mrc2 |
17534 |
Knockout |
Delayed re-epithelialization; altered stiffness of the scar tissue; no difference in total collagen content of the wounds |