| Fga |
14161 |
Knockout |
Altered pattern of epithelial cell migration and increased epithelial hyperplasia; granulation tissue failed to adequately close the wound gap, resulting in persistent open wounds or partially covered sinus tracts; reduced tensile strength |
| Fgf2 |
14173 |
Knockout |
Delayed wound healing |
| Fgfr1 |
14182 |
Knockout |
Delayed wound healing; impaired wound contraction and a delay in re-epithelialization |
| Fgfr1op2 |
675026 |
Overexpression |
Accelerated wound closure; limited granulation tissue formation |
| Fgfr2 |
14183 |
Knockout |
Delayed reepithelialization; abnormalities in the hair follicles; dermal hyperthickening |
| Fgfr2 |
14183 |
Knockout |
Delayed wound healing and re-epithelialization; impaired wound contraction |
| Fhl2 |
14200 |
Knockout |
Impaired collagen contraction and cell migration; reduced expression of α-SMA |
| Flii |
100044937 |
Knockout; antibody treatment |
Intradermal injection of Flii-neutralizing antibodies to burn wounds improved their healing; Knockout: TGF-beta1 protein and gene expression were reduced while aTGF-beta3 was elevated; decreased anti-α-SMA |
| Flna |
192176 |
Knockout |
Delayed wound healing |
| Fmod |
14264 |
Knockout |
Delayed wound closure and significantly increased scar size |
| Fn1 |
14268 |
Mutation |
Abnormal wound healing |
| Fntb |
639541 |
Knockout |
Delayed wound healing |
| Foxo1 |
56458 |
Knockout |
Accelerated wound healing with enhanced keratinocyte migration; reduced granulation tissue formation; decreased collagen density; attenuated inflammatory response (only in heterozygous knockout) |
| Foxo3 |
56484 |
Knockout |
Accelerated wound healing |
| Fpr1 |
14293 |
Double Knockout |
Delayed wound healing in double KO; no effect in single KO |
| Fpr2 |
14289 |
Double Knockout |
Delayed wound healing in double KO; no effect in single KO |
| Fst |
14313 |
Knockout |
Delayed wound healing; reduced granulation tissue formation; reduction in wound breaking strength; smaller scar area |
| Gja1 |
14609 |
Knockout |
Accelerated wound closure |
| Gjb3 |
14620 |
Mutation |
Accelerated wound healing |
| Gpr39 |
71111 |
Knockout |
Delayed wound healing during the intermediate stage |
| Grhl3 |
230824 |
Knockout |
Deficient wound repair and defective skin barrier function |
| H2-Eb1 |
14969 |
Knockout |
Impaired wound collagen deposition and breaking strength; diminished mitogen-reactivity of splenic T-cells |
| Has1 |
15116 |
Overexpression |
Promotion of dermal regeneration; decreased inflammatory response; recapitulation of fetal extracellular matrix HMW-HA content |
| Hbegf |
15200 |
Knockout |
Impaired wound closure |
| Hdc |
15186 |
Knockout; overexpression |
Knockout: Delayed wound healing; Overexpression: accelerated wound healing |
| Hgf |
15234 |
Overexpression |
Increased granulation tissue with marked vascularization |
| Hif1a |
15251 |
Knockout |
Accelerated wound closure and re-epithelialization |
| Hif1a |
15251 |
Knockout |
Impaired wound closure and revascularization of ischemic tissue |
| Hmmr |
15366 |
Knockout |
Aberrant granulation tissue; defective activation of fibroblast migration/differentiation |
| Hmox1 |
15368 |
Knockout; overexpression; inhibitor administration |
Inhibition and knockout: delayed wound closure; Overexpression: accelerated wound closure and improved neovascularization |
| Hmox2 |
15369 |
Knockout |
Delayed wound closure; reduced collagen deposition and vessel density |
| Hoxa3 |
15400 |
Overexpression |
Acceleration of diabetic wound closure |
| Hoxb13 |
15408 |
Knockout; overexpression |
Enhanced wound healing and high levels of hyaluronan; reduced long-term scarring |
| Hoxd3 |
15434 |
Overexpression |
Acceleration of diabetic wound closure |
| Hpse |
15442 |
Antibody treatment |
Improved wound healing |
| Hspb1 |
15507 |
Knockout |
Delayed wound healing; reduced re-epithelialisation and collagen deposition; increased inflammation; augmented neutrophil infiltration in wounds |
| Hspg2 |
15530 |
Knockout |
Delayed wound healing and defective angiogenesis |
| Icam1 |
15894 |
Knockout |
Delayed wound healing |
| Icos |
54167 |
Knockout |
Delayed wound healing, especially at early times; suppressed keratinocyte migration, angiogenesis and granulation tissue formation; diminished T-cell, macrophage and neutrophil infiltration; Marked suppression of cytokine expression in wounds, especially the Th2 cytokines interleukin (IL)-4; IL-6; and IL-10 |
| Icosl |
50723 |
Knockout |
Delayed wound healing, especially at early times; suppressed keratinocyte migration, angiogenesis and granulation tissue formation; diminished T-cell, macrophage and neutrophil infiltration; Marked suppression of cytokine expression in wounds, especially the Th2 cytokines interleukin (IL)-4; IL-6; and IL-10 |
| Ido1 |
15930 |
Knockout; inhibitor administration |
Accelerated wound healing; Inhibitor administration accelerated wound healing in WT mice |
| Ifng |
15978 |
Knockout |
Accelerated wound healing; rapid granulation tissue formation; enhanced angiogenesis |
| Igf1 |
16000 |
Overexpression |
Accelerated wound healing; increased proliferation and migration of keratinocytes |
| Il10 |
16153 |
Knockout |
Accelerated wound healing; accelerated re-epithelialization and enhanced contraction of the wound tissue |
| Il15 |
16168 |
Overexpression |
Accelerated wound healing |
| Il1r1 |
16177 |
Knockout |
Improved restoration of normal skin architecture with lower levels of collagen in wounds |
| Il1rn |
16181 |
Knockout |
Attenuated collagen deposition and delayed neovascularization; exaggerated neutrophil recruitment with augmented expression of IL-1s, TNF-alpha, and CXC chemokines (MIP-2 and KC) |
| Il22 |
50929 |
Knockout |
Defects in the dermal compartment after wounding |
| Il33 |
77125 |
Protein administration |
Accelerated wound healing with enhanced re-epithelialization |
| Il4 |
16189 |
Double Knockout |
Poor scar histology and increased inflammation |
| Il5 |
16191 |
Knockout; overexpression |
IL-5 overexpression vs. knockout: delayed wound healing with impaired re-epithelialization; delay in collagen deposition; increase in inflammatory cell infiltration; altered inflammatory response |
| Il6 |
16193 |
Knockout |
Delayed wound healing; minimal epithelial bridge formation; decreased inflammation, and granulation tissue formation |
| Il6ra |
16194 |
Knockout; antibody treatment |
Attenuates the delayed wound healing phenotype of IL6 knockout |
| Ilk |
621824 |
Knockout |
Delayed wound closure; decrease in cellular proliferation and loss of HGF protein expression |
| Inhba |
16323 |
Overexpression |
Enhanced granulation tissue formation; premature induction of fibronectin and tenascin-C; thickening of the epidermis; increased spinous cell layer; disorganized epidermal architecture |
| Itch |
16396 |
Knockout |
Accelerated wound healing with a delay in epithelial remodeling |
| Itga11 |
319480 |
Knockout |
Reduced granulation tissue formation and impaired wound contraction; dermal fibroblasts are unable to efficiently convert to myofibroblasts, resulting in scar tissue with compromised tensile strength |
| Itga3 |
16400 |
Knockout |
Impaired wound healing |
| Itga9 |
104099 |
Knockout |
Thinner migrating epithelium; reduction in the number of proliferating epidermal keratinocytes |
| Itgam |
16409 |
Knockout |
Delayed wound healing |
| Itgb1 |
16412 |
Knockout |
Impaired wound healing |
| Itgb2 |
16414 |
Knockout |
Impaired wound healing |
| Itgb3 |
16416 |
Knockout |
Accelerated wound healing and re-epithelialization |
| Itgb6 |
16420 |
Knockout |
Delayed wound healing; the most significant delay was observed at the stages where granulation tissue deposition was occurring |
| Jun |
16476 |
Knockout |
Defects in epidermal wound healing |
| Junb |
16477 |
Knockout |
Delayed tissue remodelling; pronounced epidermal hyperproliferation after treatment with the phorbol ester 12-O-decanoyl-phorbol-13-acetate; disturbed differentiation; prolonged inflammation |
| Kit |
16590 |
Antibody treatment |
Reduced mast cell accumulation at the edge of healing wounds |
| Kl |
16591 |
Knockout |
Delayed wound closure; reduced collagen deposition in the wounds; Phenotypic similarities with aged skin |
| Klf10 |
21847 |
Knockout |
Lower wound breaking strength |
| Klf10 |
21847 |
Knockout |
Delay in wound closure; impaired wound contraction, granulation tissue formation, collagen synthesis, and reepithelialization |
| Klf4 |
16600 |
Knockout |
Delayed wound healing; decreased stem cell-enriched population |
| Klf4 |
16600 |
Knockout |
Delayed wound healing; decreased accumulation of Myeloid-derived suppressor cells and fibrocytes |
| Klk8 |
259277 |
Knockout |
Delayed wound healing; defective keratinocyte proliferation, differentiation, and migration in the early stages of wound healing |
| Krt6a |
16687 |
Knockout |
Delay in re-epithelialization only from the hair follicle; healing of wounds was not impaired |
| Krt76 |
77055 |
Knockout |
Impaired wound healing; neonatal skin flaking; hyperpigmentation, inflammation, and death prior to 12 weeks of age |
| Lep |
16846 |
Knockout; protein administration; antibody treatment |
Knockout: Delayed wound healing; mild diabetic phenotype; systemically and topically supplemented leptin improved re-epithelialization of wounds in knockout mice; topically supplemented leptin accelerated normal wound-healing |
| Lgals1 |
16852 |
Knockout |
Delayed wound healing |
| Lgals3bp |
19039 |
Knockout |
Delayed wound healing; reduced collagen expression |
| Lgals7 |
16858 |
Knockout |
Reduced reepithelialization potential; defect in cell migration |
| Lpp |
210126 |
Knockout |
Reduced embryonic fibroblast migration |
| Lsp1 |
16985 |
Knockout |
Accelerated wound healing and re-epithelialization; increased collagen synthesis and angiogenesis |
| Lum |
17022 |
Knockout |
Delayed wound healing; increase in inflammatory macrophages; delayed response of the expression of TGF-β1, type I collagen α1 and fibronectin |
| Map3k1 |
26401 |
siRNA knockdown |
Delayed wound closure; impaired activation of Jun NH2-terminal kinases, induction of plasminogen activator inhibitor (PAI)-1, and restoration of cell-cell junctions of the wounded epidermis |
| Map3k5 |
675366 |
Knockout |
Retardation of wounding-induced hair regrowth |
| Map3k7 |
666611 |
Knockout |
Impaired wound healing; decreased collagen deposition, α-SMA and CCN2 expression |
| Mapkapk2 |
17164 |
Knockout |
Higher level of acanthosis of the migrating wound keratinocyte layer; higher level of collagen deposition in the granulation tissue |
| Med1 |
19014 |
Knockout |
Accelerated wound closure and re-epithelialization |
| Met |
17295 |
Knockout |
Keratinocytes were unable to contribute to re-epithelialization; wound closure was slightly attenuated, but occurred exclusively by a few (5%) keratinocytes that had escaped recombination |
| Mfap2 |
17150 |
Knockout |
Altered wound healing response |
| Mfge8 |
17304 |
Knockout |
Delayed wound healing; reduced myofibroblast and vessel numbers |
| Mgat5 |
107895 |
Overexpression |
Accelerated wound healing |
| Mif |
100040259 |
Knockout |
Delayed wound healing |
| Mir155 |
387173 |
Knockout |
Accelerated wound closure; elevated numbers of macrophages |
| Mir21a |
387140 |
Overexpression; antagonist andministration |
Overexpression of miR-21: stronger wound contraction; antagomiR administration: delay of wound closure with impaired collagen deposition |
| Mmp13 |
17386 |
Knockout |
Delayed wound healing |
| Mmp1a |
83995 |
Mutation |
Delayed wound healing (in mice expressing the human gene in the epidermis) |
| Mmp3 |
17392 |
Knockout |
Wounds failed to contract and healed more slowly |
| Mmp8 |
17394 |
Knockout |
Impaired wound healing |
| Mmp9 |
17395 |
Knockout |
Delayed wound healing; defect in keratinocyte migration |
| Mrc2 |
17534 |
Knockout |
Delayed re-epithelialization; altered stiffness of the scar tissue; no difference in total collagen content of the wounds |
