Browse Mus musculus genes (319)


Gene symbol Entrez ID Intervention Effect on wound healing
Mstn 17700 Knockout Delayed wound healing; delayed epidermal reepithelialization and dermal contraction
Msx2 17702 Knockout Accelerated wound closure and re-epithelialization; earlier appearance of keratin markers for differentiation and an increased level of smooth muscle actin and tenascin in the granulation tissue
Myb 17863 Knockout Heterozygous c-myb deficiency has a functional effect on wound repair; collagen type I levels and transforming growth factor-beta1 expression are elevated
Myc 17869 Knockout Impaired wound healing
Myd88 17874 Knockout Delayed wound healing; delayed contraction; decreased and delayed granulation tissue formation; reduced new blood vessel density
Ncoa3 17979 Knockout Delayed wound healing
Ncoa6 56406 Knockout Spontaneous natural wounds healing defects
Nf1 18015 Knockout Abnormal pattern and amount of collagen-rich granulation bed tissue; skin wound fibroblasts proliferated past the normal wound maturation phase
Nfe2l2 18024 Knockout Prolonged inflammation in the late phase of repair; reduced expression of various key players in the early phase;
Nfic 18029 Knockout Accelerated wound closure; faster inflammatory stage; increased expression of PDGFA and PDGF-receptor alpha; reduced differentiation of fibroblasts to myofibroblasts
Nid1 18073 Knockout hyperproliferation of the newly formed epidermis with a delay in differentiation at day 10 post injury; considerable alpha-smooth muscle actin staining in the dermis of wounds
Nlrp3 216799 Knockout Delayed re-epithelialization, granulation tissue formation, and angiogenesis
Nos1 18125 Knockout Delayed wound closure
Nos2 18126 Knockout Delayed wound closure
Nos3 18127 Knockout Delayed wound closure
Npy2r 18167 Knockout Delayed wound closure with reduced neovascularization
Nr3c1 14815 Mutation Enlarged granulation tissue with a high fibroblast density; late wounds appeared normal; enhanced ability of fibroblasts to contract collagen
Nr3c1 14815 Overexpression Delayed wound healing; delayed re-epithelialization and formation of granulation tissue; reduced recruitment of granulocytes and macrophages; TGF-β1 and Kgf expression was repressed whereas TGF-β3 was up-regulated
Nr4a1 15370 Knockout; overexpression Delayed wound healing in a dominant negative mutant
Ogfr 72075 Overexpression Delayed wound healing
Oprd1 18386 Knockout Delayed wound healing; severe epidermal hypertrophy at the wound margin
P2ry2 18442 Knockout Increased wound size at day 14 post-wounding; reduction in the expression of Ki67, VEGF, collagen I, fibronectin and α-SMA
Panx1 55991 Knockout Delayed wound healing
Pear1 73182 Knockout Accelerated wound closure
Perp 64058 Knockout Delayed wound healing
Pgf 18654 Knockout Impaired angiogenesis, plasma extravasation and collateral growth
Pik3cg 30955 Mutation Delayed resolution of inflammation in wound healing; increased proliferation and decreased apoptosis
Pkd1 18763 Knockout Delayed wound re-epithelialization; reduced proliferation and migration of keratinocytes at the wound edge
Plaur 18793 Knockout Delayed wound healing
Plec 18810 Knockout Reduced leukocyte infiltration
Plg 18815 Knockout Impaired wound healing
Postn 50706 Knockout Delayed wound healing (rescued by direct administration of exogenous periostin)
Pou2f3 18988 Knockout Various effects on differentiation of epidermal keratinocytes during normal development and wound healing
Pou3f1 18991 Knockout Various effects on differentiation of epidermal keratinocytes during normal development and wound healing
Ppara 19013 Mutation Modulation of early inflammation phase
Ppard 19015 Mutation Impaired adhesion and migration properties
Pparg 19016 Knockout Impaired wound healing with reduced collagen deposition, angiogenesis and granulation formation
Ppp1r15a 17872 Knockout Accelerated wound healing; reduced amounts of myosin IIA in migrating macrophages and myofibroblasts
Prdx6 11758 Knockout Damaged endothelial cells with an enhanced rate of apoptosis; hemorrhage in the granulation tissue
Prkca 18750 Knockout Delayed granulation tissue deposition; failure to upregulate collagen and other ECM components
Prkce 18754 Knockout Delayed wound closure and a reduction in myofibroblasts
Prkch 18755 Knockout Delayed wound healing, particularly re-epithelialization
Pten 19211 Knockout Various effects indicating the importance of mTOR
Ptger3 19218 Knockout Delayed wound closure and re-epithelization; inhibited angiogenesis; reduction in immunoreactive vascular endothelial growth factor (VEGF) in granulation tissues
Ptgs1 19224 Knockout Reduced breaking strength; enhanced angiogenesis; reduced macrophages and myofibroblasts at day 12
Ptgs2 19225 Knockout Reduced breaking strength; enhanced angiogenesis; reduced macrophages and myofibroblasts at day 12
Ptk2 14083 Knockout Delayed wound healing; decreased dermal thickness and collagen density
Ptk2b 19229 Knockout Delayed wound closure
Ptk7 71461 Knockout Defective wound repair
Rac1 19353 Knockout Delayed wound closure; reduced collagen production and myofibroblast formation
Rac2 19354 Knockout Reduced wound-related lipid peroxidation
Raf1 110157 Knockout Delayed wound healing
Ramp1 51801 Knockout Suppressed wound healing and wound-induced angiogenesis; reduced expression of vascular endothelial growth factor (VEGF)-A
Reck 631094 Knockout Improved wound healing
Ripk3 56532 Knockout Delayed wound healing
S100a9 20202 Knockout Diminished recruitment of granulocytes into the granulation tissue
Scrib 105782 Knockout Defective wound repair
Sdc1 20969 Knockout Prolonged hypoplasia; delayed cell proliferation and reduced localization of alpha9 integrin in the epidermis
Sdc4 20971 Knockout Delayed wound healing and impaired angiogenesis in the granulation tissue
Sele 20339 Double Knockout Reduced recruitment of inflammatory cells and impaired wound closure in mice deficient in both P- and E-selectins
Sell 20343 Knockout Delayed wound healing
Selp 20344 Double Knockout Reduced recruitment of inflammatory cells and impaired wound closure in mice deficient in both P- and E-selectins
Sept4 18952 Knockout Improvement in wound healing and regeneration of hair follicles
Serpine1 18787 Knockout Accelerated wound closure
Serpinf2 18816 Knockout Accelerated wound closure; increased angiogenesis
Siah2 20439 Knockout Delayed wound healing; delayed induction of myofibroblast infiltration and reduced collagen deposition; delayed angiogenesis and reduced macrophage infiltration into the wounds
Slc11a1 18173 Knockout Delayed wound healing
Slc6a6 21366 Knockout Delayed wound closure in 12-mo mice; no effect in 5-mo mice
Slpi 20568 Knockout Impaired wound healing with increased inflammation and elastase activity
Smad2 17126 Overexpression Delayed wound healing; a defect in basal keratinocyte migration
Smad3 17127 Knockout Accelerated dorsal wound healing; ear wounds are enlarged resulting from changes in extracellular matrix molecules
Smad4 17128 Knockout Delayed wound closure and remodeling; increased angiogenesis and inflammation
Smad7 17131 Overexpression Accelerated re-epithelialization; increase in keratinocyte proliferation; reduced Smad2 activation; increased activation of extracellular signal-regulated kinase (Erk)
Snai2 20583 Knockout Reduced re-epithelialization; increased expression of the Slug target genes keratin 8 and E-cadherin at wound margins; 40% of mice developed non-healing cutaneous ulcers in response to chronic UVR
Socs3 12702 Overexpression Impaired wound healing; atrophied wound-margin epithelia and augmented response of keratinocytes; a prolonged persistence of neutrophils and macrophages; elevated levels of TGF-beta1
Sod1 545845 Knockout Delayed wound healing
Sorbs3 20410 Knockout Delay in wound healing in both back and tail, without affecting the proliferation of keratinocytes
Sparc 100046740 Knockout Accelerated wound closure
Sparcl1 13602 Knockout Accelerated wound healing; enhanced macrophage infiltration of wound beds at early time points; earlier appearance of mature extracellular matrix; fibrovascular invasion of polyvinyl alcohol sponges was more robust
Spi1 20375 Knockout Accelerated wound healing with reduced fibrosis; incapacity to raise the standard inflammatory response, due to a lack of macrophages and functioning neutrophils
Spi1 20375 knockout Scar-free repair; altered growth factor and cytokine profile; cell death is reduced, and dying cells are instead engulfed by stand-in phagocytic fibroblasts
Spp1 20750 Knockout Decreased level of debridement; greater disorganization of matrix; alteration of collagen fibrillogenesis leading to small diameter collagen fibrils; tensile properties of the wounds were unchanged
Stat3 20848 Knockout Compromised wound healing and hair cycle; developed spontaneously occurring ulcers with age
Tcf3 21423 Overexpression Accelerated wound healing and keratinocyte migration
Tert 21752 Overexpression Accelerated wound healing
Tgfa 21802 Knockout Ear model: delayed re-epithelialization; Head model: no difference in epithelial gap or new granulation tissue
Tgfb1 21803 Knockout Decreased granulation tissue formation, vascularity, collagen deposition, epithelialization and a marked inflammatory infiltrate
Tgfb3 21809 Protein administration Scar-free wound healing in adults
Tgfbr2 21813 Knockout Accelerated wound closure and re-epithelization; reduced collagen deposition and remodeling; reduced extent of wound contraction, and elevated macrophage infiltration
Tgm1 21816 Knockout Delayed wound healing
Thbd 21824 Knockout Delayed wound healing
Thbd 21824 Overexpression Delayed wound healing; reduced granulation tissue formation and highly diminished wound angiogenesis
Thbs1 21825 Overexpression Delayed wound healing; reduced granulation tissue formation and highly diminished wound angiogenesis
Thbs2 21826 Knockout Improved wound healing
Thra 100047427 Knockout Delayed re-epithelialization and wound closure; impaired keratinocyte proliferation
Thrb 21834 Knockout Delayed re-epithelialization and wound closure; impaired keratinocyte proliferation
Thy1 21838 siRNA treatment Impaired wound healing; the level of TGF-β1 at the wound continuously increased
Timp1 21857 Knockout Delayed wound healing with slow migration of keratinocytes over the wound
Tlr2 24088 Knockout Delayed wound healing; decreased numbers of infiltrating macrophages in the dermis and decreased TGF-β and CCL5 mRNA expression
Tlr4 21898 Knockout Delayed wound healing; decreased numbers of infiltrating macrophages in the dermis and decreased TGF-β and CCL5 mRNA expression

Contact: Vadim E. Fraifeld, MD, PhD
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