Knockout of Akt1 in Mus musculus

Gene symbol Akt1
Gene name Thymoma Viral Proto-Oncogene 1; Similar To Serine/Threonine Protein Kinase
Gene entrez ID 100047666
Gene aliases RAC, PKB, PRKBA, AKT
Organism House mouse, Mus musculus (@AnAge)
Interactions Protein-protein interaction partners (@BioGRID)

Gene symbol AKT1
HUGO gene ID 391
Gene entrez ID 207
Genecards AKT1

Intervention Knockout
Genetic background 129 R1/C57BL/6
Wound model Full-Thickness Incision
Wound Dimensions 15 mm
Wound Location Dorsum
Effect on skin wound healing Impaired assembly of collagen in skin wounds and around the blood vessels; reduced vascular area and impaired vascular maturation; lower expression of VEGF; no significant difference in migration of fibroblasts into the wound area was observed and the dynamics of wound closure were similar
References Somanath et al. 2008
Bancroft et al. 2015

Contact: Vadim E. Fraifeld, MD, PhD
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