Knockout of Bcl11b in Mus musculus

Gene symbol Bcl11b
Gene name B-Cell Leukemia/Lymphoma 11B
Gene entrez ID 58208
Gene aliases CTIP-2, CTIP2, hRIT1-alpha
Organism House mouse, Mus musculus (@AnAge)
Interactions Protein-protein interaction partners (@BioGRID)

Gene symbol BCL11B
HUGO gene ID 13222
Gene entrez ID 64919
Genecards BCL11B

Intervention Knockout
Genetic background C57BL/6
Wound model Full-Thickness Excisional Punch
Wound Dimensions 5 mm ⌀
Wound Location Dorsum
Effect on skin wound healing Defects in proliferation and migration of keratinocytes during re-epithelialization; Reduced epidermal proliferation; delayed keratinocyte activation; altered cell-cell adhesion and impaired ECM development; Post wounding: lack of E-Cadherin suppression in the migratory tongue; insufficient expression of alpha smooth muscle actin (α-SMA) in the dermis; robust induction of K8; dysregulated expression of several hair follicle (HF) stem cell markers
References Liang et al. 2012

Contact: Vadim E. Fraifeld, MD, PhD
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