Knockout; antagonist administration of Calca in Mus musculus

Gene symbol Calca
Gene name Calcitonin/Calcitonin-Related Polypeptide, Alpha
Gene entrez ID 12310
Gene aliases FLJ30166, CGRP-II
Organism House mouse, Mus musculus (@AnAge)
Interactions Protein-protein interaction partners (@BioGRID)

Gene symbol CALCB
HUGO gene ID 1438
Gene entrez ID 797
Genecards CALCB

Intervention Knockout; antagonist administration
Genetic background C57BL/6
Wound model Full-Thickness Excisional Punch
Wound Dimensions 8 mm ⌀
Wound Location Dorsum
Effect on skin wound healing Suppressed angiogenesis and wound closure; reduction in expressions of vascular endothelial growth factor (VEGF) in the wound granulation tissues; Antagonist administration (when infused with mini-osmotic pumps) subcutaneously blocked the wound healing processes and reduced the expressions of CD31 and VEGF expression in the wound granulation tissues
References Toda et al. 2008

Contact: Vadim E. Fraifeld, MD, PhD
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