Overexpression of Cast in Mus musculus

Gene symbol Cast
Gene name Calpastatin
Gene entrez ID 12380
Gene aliases 0
Organism House mouse, Mus musculus (@AnAge)
Interactions Protein-protein interaction partners (@BioGRID)

Gene symbol CAST
HUGO gene ID 1515
Gene entrez ID 831
Genecards CAST

Intervention Overexpression
Genetic background C57BL/6
Wound model Full-Thickness Excisional Punch
Wound Dimensions 5 mm ⌀
Wound Location Dorsum
Effect on skin wound healing Delay in wound healing, particularly in the initial steps; reduced proliferation in the epidermis and delayed re-epithelization; impaired granulation tissue formation; reduction in CD45+ leukocyte infiltrate and in CD31+ blood vessel density; reduction in α-SMA expressing myofibroblasts
References Nassar et al. 2012

Contact: Vadim E. Fraifeld, MD, PhD
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