Antibody treatment, protein administration of Tgfb1 in Rattus norvegicus

Gene symbol Tgfb1
Gene name Transforming Growth Factor, Beta 1
Gene entrez ID 59086
Gene aliases CED, TGFbeta
Organism Norway rat, Rattus norvegicus (@AnAge)
Interactions Protein-protein interaction partners (@BioGRID)

Gene symbol TGFB1
HUGO gene ID 11766
Gene entrez ID 7040
Genecards TGFB1

Intervention Antibody treatment, protein administration
Genetic background Sprague-Dawley
Wound model Full-Thickness Incision
Wound Dimensions 1 cm^2
Wound Location Dorsum
Effect on skin wound healing Neutralising TGF-beta 1: reduced the monocyte and macrophage profile, neovascularisation, fibronectin, collagen III and collagen I deposition in the early stages of wound healing; improved the architecture of the neodermis to resemble that of normal dermis and reduced scarring; effect was stronger when comined with TG-beta 2 neutralization; Protein treatment: more extracellular matrix deposition in the early stages of wound healing but did not differ from control wounds in the final quality of scarring
References Shah et al. 1995

Contact: Vadim E. Fraifeld, MD, PhD
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