Browse all genes (383)


Gene symbol Entrez ID Intervention Effect on wound healing Organism
Esr1 13982 various Various Mus musculus
Adam9 11502 Knockout Accelerated re-epithelialization and wound repair Mus musculus
Adamts1 11504 Knockout Delayed wound closure and increased angiogenic response Mus musculus
Adamts1 11504 Knockout Keratinocyte differentiation abnormalities Mus musculus
Adamts5 632263 Knockout Impaired contraction and dermal collagen deposition Mus musculus
Adipoq 11450 Knockout; protein administration Delay in wound closure; impaired keratinocyte proliferation and migration Mus musculus
Adora2a 11540 Knockout; agonist administration Knockout: delayed the course of skin wound healing; agonist: promoted the course of skin wound healing Mus musculus
Adra2a 11551 Knockout Accelerated wound contraction and re-epithelialization Mus musculus
Adra2c 11553 Knockout Accelerated wound contraction and re-epithelialization Mus musculus
Adrb2 11555 Knockout; antagonist administration Promotion of wound repair; increased angiogenesis, dermal fibroblast function and re-epithelialization; no effect on wound inflammation Mus musculus
Aebp1 11568 Knockout Deficient wound healing Mus musculus
Agtr1a 11607 Knockout; antagonist administration Suppressed wound healing and angiogenesis; delayed wound healing after antagonist administration Mus musculus
Ahr 11622 Knockout; antisense silencing Accelerated re-epithelialization; increased keratinocyte migration; increased collagen content in the granulation tissue Mus musculus
Aimp1 13722 Knockout; protein administration Knockout: delayed wound healing; Protein administration: stimulated dermal fibroblast proliferation, collagen production, and wound closure Mus musculus
Akt1 100047666 Knockout Impaired assembly of collagen in skin wounds and around the blood vessels; reduced vascular area and impaired vascular maturation; lower expression of VEGF; no significant difference in migration of fibroblasts into the wound area was observed and the dynamics of wound closure were similar Mus musculus
Alox5 11689 Knockout Accelerated wound healing with an upregulation of heme oxygenase-1 (HO-1) Mus musculus
Angpt1 11600 Overexpression Under nondiabetic conditions, combining Ang1 and VEGF overexpression resulted in accelerated wound closure Mus musculus
Angptl4 57875 Knockout; siRNA knockdown; antibody treatment Delayed wound reepithelialization with impaired keratinocyte migration; diminished integrin-mediated signaling Mus musculus
Angptl6 70726 Knockout Accelerated wound closure; thickened epidermis and a marked increase in proliferating epidermal cells as well as vascular cells Mus musculus
Ankrd1 107765 Knockout Extensive necrosis of ischemic skin flaps and delayed wound closure; decreased contraction and reduced granulation tissue thickness Mus musculus
Anpep 16790 Antibody treatment Accelerated wound closure; increase of collagen deposition and fibroblast contractility in the granulation tissue Mus musculus
Anxa1 16952 Knockout Delayed wound healing; impaired endothelial cell sprouting Mus musculus
Aqp3 11828 Knockout Delayed wound healing Mus musculus
Ar 11835 Knockout Accelerated wound healing; enhanced inflammatory response through a localized increase in TNF-alpha expression; no acceleration in keratinocyte- and fibroblast-specific knockouts Mus musculus
Arhgap1 667205 Knockout Delayed re-epithelialization in the wound edge 4 days after wounding Mus musculus
Arnt 11863 Knockout Deficient infiltration of cells during the early phases of wound healing; neoangiogenic deficiencies alongside a reduction in numbers of proangiogenic progenitor cells from bone marrow and peripheral blood samples Mus musculus
Arnt 11863 Knockdown Delayed wound healing Mus musculus
Arrb2 216869 Knockout Accelerated wound re-epithelialization Mus musculus
Asprv1 67855 Overexpression Delayed wound healing Mus musculus
B4galt1 14595 Knockout Delayed wound healing; reduced re-epithelialization, collagen synthesis, and angiogenesis; impaired recruitment of neutrophils and macrophages Mus musculus
Bcl11b 58208 Knockout Defects in proliferation and migration of keratinocytes during re-epithelialization; Reduced epidermal proliferation; delayed keratinocyte activation; altered cell-cell adhesion and impaired ECM development; Post wounding: lack of E-Cadherin suppression in the migratory tongue; insufficient expression of alpha smooth muscle actin (α-SMA) in the dermis; robust induction of K8; dysregulated expression of several hair follicle (HF) stem cell markers Mus musculus
Bmp6 12161 Overexpression Delayed re-epitheliazation Mus musculus
Bmx 12169 Overexpression Accelerated re-epithelialization and keratinocyte proliferation; chronic inflammation and angiogenesis in the skin Mus musculus
Bub1b 12236 Hypermorphic mutation Delayed wound healing Mus musculus
C1qa 12259 Knockout Defective blood vessel formation Mus musculus
C3 12266 Knockout Accelerated early stages of wound healing; reduction in inflammatory infiltrate; increased accumulation of mast cells and advanced angiogenesis Mus musculus
C5ar1 12273 Knockout Accelerated early stages of wound healing; reduction in inflammatory infiltrate; increased accumulation of mast cells and advanced angiogenesis Mus musculus
Cadm1 54725 Knockout; overexpression Both knockout and overexpression led to a markedly delayed wound healing Mus musculus
Calca 12310 Knockout; antagonist administration Suppressed angiogenesis and wound closure; reduction in expressions of vascular endothelial growth factor (VEGF) in the wound granulation tissues; Antagonist administration (when infused with mini-osmotic pumps) subcutaneously blocked the wound healing processes and reduced the expressions of CD31 and VEGF expression in the wound granulation tissues Mus musculus
Cap2 67252 Knockout Altered wound healing response presumably resulting from reduced levels of α-SMA; decreased macrophage infiltration and slower neovascularization Mus musculus
Car8 676792 Overexpression Induction of neovascularization Mus musculus
Casp1 100044207 Knockout Delayed re-epithelialization, granulation tissue formation, and angiogenesis Mus musculus
Cast 12380 Overexpression Delay in wound healing, particularly in the initial steps; reduced proliferation in the epidermis and delayed re-epithelization; impaired granulation tissue formation; reduction in CD45+ leukocyte infiltrate and in CD31+ blood vessel density; reduction in α-SMA expressing myofibroblasts Mus musculus
Cav1 12389 Knockout Accelerated wound healing; increased NO production; increased MMP-13 nitration Mus musculus
Ccl17 20295 Overexpression Accelerated wound closure; increase in CCR4(+) fibroblasts, CCR4(+) lymphocytes, NGF(+) lymphocytes, and mast cells Mus musculus
Ccl2 20296 Knockout Delayed wound re-epithelialization and angiogenesis; collagen synthesis was impeded with wounds containing significantly less hydroxyproline; no change in the number of wound macrophages Mus musculus
Cd109 235505 Overexpression Hypoxic wounds in both transgenic and wild-type mice increased levels of HIF-1α and delayed wound closure; Hypoxic wounds in transgenic mice decreased collagen type 1 and fibronectin expression and reduced dermal thickness on day 7 post-wounding Mus musculus
Cd151 12476 Knockout Defective wound healing Mus musculus
Cd19 12478 Knockout; overexpression Knockout: delayed wound healing and inhibition in infiltration of neutrophils, macrophages, and cytokine expression; Overexpression: enhanced wound healing and cytokine expression Mus musculus
Cd24a 12484 Knockout; overexpression Knockout: delay in the formation of granulation tissue and wound closure; failure to maintain stitches; Overexpression: improvemment in healing Mus musculus
Cd44 12505 Knockout Decrease in skin elasticity; impaired local inflammatory response and tissue repair; delayed hair regrowth Mus musculus
Cd47 16423 Knockout Accelerated wound closure; increased blood flow; increased fibrosis Mus musculus
Cd9 12527 Knockout Delayed wound healing and defective re-epithelialization Mus musculus
Cdkn1b 12576 Mutation Delayed wound closure by defective regrowth of epithelial cells Mus musculus
Ceacam1 26367 Knockout Delayed re-epithelialization; decreased infiltration of F4/80(+) macrophages; altered inflammatory processes; diminished vascular density of the granulation tissue Mus musculus
Cebpg 12611 siRNA knockdown Impaired wound healing; inhibition of both re-epithelialization and granulation tissue formation; decrease of arteriole number Mus musculus
Celsr1 12614 Knockout Defective embryonic wound repair Mus musculus
Cftr 12638 Knockout Delayed wound healing Mus musculus
Chrm3 12671 Knockout Accelerated epithelialization Mus musculus
Chrm4 12672 Knockout Delayed re-epithelialization Mus musculus
Clec3b 21922 Knockout Delayed wound healing Mus musculus
Clic4 29876 Knockout Delayed re-epithelialization; delayed resolution of inflammation Mus musculus
Cmah 12763 Knockout Delayed wound healing Mus musculus
Col18a1 12822 Knockout; overexpression Overexpression: delayed wound healing; Knockdown: accelerated wound healing and accelerated vascularisation Mus musculus
Col1a1 12842 Mutation Delayed wound healing and re-epithelialization; prolonged early inflammatory response Mus musculus
Col7a1 12836 Knockout Defects in dermal fibroblast migration and cytokine production in the granulation tissue; perturbation of laminin-332 organization during wound healing; strictly polarized expression of integrin α6β4 in basal keratinocytes Mus musculus
Csf2 12981 Knockout; overexpression Knockout: Delayed wound healing; overexpression (in the basal layer of the epidermis): accelerated re-epithelialization Mus musculus
Ctnnb1 12387 Knockout Affected the TGF-beta wound healing response Mus musculus
Ctsg 13035 Knockout Decrease in wound-breaking strength; increase in neutrophil myeloperoxidase activity and influx Mus musculus
Cx3cl1 20312 Knockout; antibody treatment Delayed wound closure; reduced α-SMA and collagen deposition; reduced neovascularization Mus musculus
Cxcl10 100045000 Overexpression Prolonged and disorganized granulation phase with impaired blood vessel formation; intensified inflammatory phase Mus musculus
Cxcl11 56066 Knockout Delayed re-epithelialization; hypercellular and immature dermis noted even after 60 days; provisional matrix components persisted in the dermis, and the mature basement membrane components laminin V and collagen IV were severely diminished Mus musculus
Cxcr2 12765 Knockout Delay in re-epithelialization and decreased neovascularization Mus musculus
Cxcr3 12766 Knockout Thick keratinized scar with a thickening of both the epidermis and dermis; the dermis was disorganized with thick and long collagen fibrils and contained excessive collagen content; Pesented lower tensile/burst strength Mus musculus
Cxxc5 67393 Knockout Accelerated wound healing; enhanced keratin 14 and collagen synthesis Mus musculus
Cyr61 16007 Mutation Exacerbated fibrosis Mus musculus
Dact2 240025 Knockout Accelerated re-epithelialization Mus musculus
Ddr2 18214 Knockout Reduced proliferative response Mus musculus
Dmd 13405 Knockout Accelerated wound closure Mus musculus
Dst 13518 Knockout Delayed wound healing Mus musculus
E2f1 13555 Knockout Delayed re-epithelialization; reduced local inflammatory responses Mus musculus
Edil3 13612 Overexpression Normal wound healing; increased rate of hair regrowth Mus musculus
Edn1 13614 Double overexpression Accelerated wound closure; increased fibrogenesis; excessive scarring Mus musculus
Edn1 13614 Knockout Accelerated wound healing, indicated by earlier granulation tissue reduction and re-epithelialization; bleomycin-injected fibrotic skin showed decreased skin thickness and collagen content Mus musculus
Egfr 13649 Knockout Modified both normal and wound-induced epidermal proliferation Mus musculus
Egln1 112405 Knockout Accelerated wound closure Mus musculus
Egr1 13653 Knockout; overexpression Knockout: Impaired wound healing; overexpression: exuberant tissue repair, with enhanced collagen accumulation and increased tensile strength of incisional wounds Mus musculus
Eif3e 16341 siRNA treatment Accelerated wound closure; promoted neoangiogenesis in the area surrounding the injury, including in genetically diabetic mice Mus musculus
Eng 13805 Knockout Delay in wound healing; keratinocytes at the wound edges exhibited impaired proliferation but were more migratory Mus musculus
Epas1 13819 Knockout Accelerated wound closure; reduced inflammatory response Mus musculus
Epb41 269587 Knockout Defective epidermal wound healing; impaired cell adhesion, spreading, migration and motility in keratinocyts Mus musculus
Epo 13856 Protein administration Single-high-dose treatment accelerated wound epithelialization and induced maturation of newly formed microvascular networks. In contrast, repeated-high-dose impaired the healing process, delayed re-epithelialization with a lack of maturation of microvascular networks Mus musculus
Eppk1 223650 Knockout Rapid wound closure Mus musculus
Ereg 13874 Protein administration Greater epidermal proliferation and thickening Mus musculus
Acvr1b 11479 Overexpression of a dominant negative Delayed re-epithelialization Mus musculus
F13a1 74145 Knockout Impaired wound healing Mus musculus
F7 14068 Knockout Defective re-epithelialization and reduced inflammatory cell infiltration Mus musculus
F9 14071 Knockout Impaired wound healing Mus musculus
Fam129b 227737 Knockout Delayed wound healing Mus musculus
Fga 14161 Knockout Altered pattern of epithelial cell migration and increased epithelial hyperplasia; granulation tissue failed to adequately close the wound gap, resulting in persistent open wounds or partially covered sinus tracts; reduced tensile strength Mus musculus
Fgf2 14173 Knockout Delayed wound healing Mus musculus
Fgfr1 14182 Knockout Delayed wound healing; impaired wound contraction and a delay in re-epithelialization Mus musculus
Fgfr1op2 675026 Overexpression Accelerated wound closure; limited granulation tissue formation Mus musculus
Fgfr2 14183 Knockout Delayed reepithelialization; abnormalities in the hair follicles; dermal hyperthickening Mus musculus
Fgfr2 14183 Knockout Delayed wound healing and re-epithelialization; impaired wound contraction Mus musculus
Fhl2 14200 Knockout Impaired collagen contraction and cell migration; reduced expression of α-SMA Mus musculus
Flii 100044937 Knockout; antibody treatment Intradermal injection of Flii-neutralizing antibodies to burn wounds improved their healing; Knockout: TGF-beta1 protein and gene expression were reduced while aTGF-beta3 was elevated; decreased anti-α-SMA Mus musculus
Flna 192176 Knockout Delayed wound healing Mus musculus
Fmod 14264 Knockout Delayed wound closure and significantly increased scar size Mus musculus
Fn1 14268 Mutation Abnormal wound healing Mus musculus
Fntb 639541 Knockout Delayed wound healing Mus musculus
Foxo1 56458 Knockout Accelerated wound healing with enhanced keratinocyte migration; reduced granulation tissue formation; decreased collagen density; attenuated inflammatory response (only in heterozygous knockout) Mus musculus
Foxo3 56484 Knockout Accelerated wound healing Mus musculus
Fpr1 14293 Double Knockout Delayed wound healing in double KO; no effect in single KO Mus musculus
Fpr2 14289 Double Knockout Delayed wound healing in double KO; no effect in single KO Mus musculus
Fst 14313 Knockout Delayed wound healing; reduced granulation tissue formation; reduction in wound breaking strength; smaller scar area Mus musculus
Gja1 14609 Knockout Accelerated wound closure Mus musculus
Gjb3 14620 Mutation Accelerated wound healing Mus musculus
Gpr39 71111 Knockout Delayed wound healing during the intermediate stage Mus musculus
Grhl3 230824 Knockout Deficient wound repair and defective skin barrier function Mus musculus
H2-Eb1 14969 Knockout Impaired wound collagen deposition and breaking strength; diminished mitogen-reactivity of splenic T-cells Mus musculus
Has1 15116 Overexpression Promotion of dermal regeneration; decreased inflammatory response; recapitulation of fetal extracellular matrix HMW-HA content Mus musculus
Hbegf 15200 Knockout Impaired wound closure Mus musculus
Hdc 15186 Knockout; overexpression Knockout: Delayed wound healing; Overexpression: accelerated wound healing Mus musculus
Hgf 15234 Overexpression Increased granulation tissue with marked vascularization Mus musculus
Hif1a 15251 Knockout Accelerated wound closure and re-epithelialization Mus musculus
Hif1a 15251 Knockout Impaired wound closure and revascularization of ischemic tissue Mus musculus
Hmmr 15366 Knockout Aberrant granulation tissue; defective activation of fibroblast migration/differentiation Mus musculus
Hmox1 15368 Knockout; overexpression; inhibitor administration Inhibition and knockout: delayed wound closure; Overexpression: accelerated wound closure and improved neovascularization Mus musculus
Hmox2 15369 Knockout Delayed wound closure; reduced collagen deposition and vessel density Mus musculus
Hoxa3 15400 Overexpression Acceleration of diabetic wound closure Mus musculus
Hoxb13 15408 Knockout; overexpression Enhanced wound healing and high levels of hyaluronan; reduced long-term scarring Mus musculus
Hoxd3 15434 Overexpression Acceleration of diabetic wound closure Mus musculus
Hpse 15442 Antibody treatment Improved wound healing Mus musculus
Hspb1 15507 Knockout Delayed wound healing; reduced re-epithelialisation and collagen deposition; increased inflammation; augmented neutrophil infiltration in wounds Mus musculus
Hspg2 15530 Knockout Delayed wound healing and defective angiogenesis Mus musculus
Icam1 15894 Knockout Delayed wound healing Mus musculus
Icos 54167 Knockout Delayed wound healing, especially at early times; suppressed keratinocyte migration, angiogenesis and granulation tissue formation; diminished T-cell, macrophage and neutrophil infiltration; Marked suppression of cytokine expression in wounds, especially the Th2 cytokines interleukin (IL)-4; IL-6; and IL-10 Mus musculus
Icosl 50723 Knockout Delayed wound healing, especially at early times; suppressed keratinocyte migration, angiogenesis and granulation tissue formation; diminished T-cell, macrophage and neutrophil infiltration; Marked suppression of cytokine expression in wounds, especially the Th2 cytokines interleukin (IL)-4; IL-6; and IL-10 Mus musculus
Ido1 15930 Knockout; inhibitor administration Accelerated wound healing; Inhibitor administration accelerated wound healing in WT mice Mus musculus
Ifng 15978 Knockout Accelerated wound healing; rapid granulation tissue formation; enhanced angiogenesis Mus musculus
Igf1 16000 Overexpression Accelerated wound healing; increased proliferation and migration of keratinocytes Mus musculus
Il10 16153 Knockout Accelerated wound healing; accelerated re-epithelialization and enhanced contraction of the wound tissue Mus musculus
Il15 16168 Overexpression Accelerated wound healing Mus musculus
Il1r1 16177 Knockout Improved restoration of normal skin architecture with lower levels of collagen in wounds Mus musculus
Il1rn 16181 Knockout Attenuated collagen deposition and delayed neovascularization; exaggerated neutrophil recruitment with augmented expression of IL-1s, TNF-alpha, and CXC chemokines (MIP-2 and KC) Mus musculus
Il22 50929 Knockout Defects in the dermal compartment after wounding Mus musculus
Il33 77125 Protein administration Accelerated wound healing with enhanced re-epithelialization Mus musculus
Il4 16189 Double Knockout Poor scar histology and increased inflammation Mus musculus
Il5 16191 Knockout; overexpression IL-5 overexpression vs. knockout: delayed wound healing with impaired re-epithelialization; delay in collagen deposition; increase in inflammatory cell infiltration; altered inflammatory response Mus musculus
Il6 16193 Knockout Delayed wound healing; minimal epithelial bridge formation; decreased inflammation, and granulation tissue formation Mus musculus
Il6ra 16194 Knockout; antibody treatment Attenuates the delayed wound healing phenotype of IL6 knockout Mus musculus
Ilk 621824 Knockout Delayed wound closure; decrease in cellular proliferation and loss of HGF protein expression Mus musculus
Inhba 16323 Overexpression Enhanced granulation tissue formation; premature induction of fibronectin and tenascin-C; thickening of the epidermis; increased spinous cell layer; disorganized epidermal architecture Mus musculus
Itch 16396 Knockout Accelerated wound healing with a delay in epithelial remodeling Mus musculus
Itga11 319480 Knockout Reduced granulation tissue formation and impaired wound contraction; dermal fibroblasts are unable to efficiently convert to myofibroblasts, resulting in scar tissue with compromised tensile strength Mus musculus
Itga3 16400 Knockout Impaired wound healing Mus musculus
Itga9 104099 Knockout Thinner migrating epithelium; reduction in the number of proliferating epidermal keratinocytes Mus musculus
Itgam 16409 Knockout Delayed wound healing Mus musculus
Itgb1 16412 Knockout Impaired wound healing Mus musculus
Itgb2 16414 Knockout Impaired wound healing Mus musculus
Itgb3 16416 Knockout Accelerated wound healing and re-epithelialization Mus musculus
Itgb6 16420 Knockout Delayed wound healing; the most significant delay was observed at the stages where granulation tissue deposition was occurring Mus musculus
Jun 16476 Knockout Defects in epidermal wound healing Mus musculus
Junb 16477 Knockout Delayed tissue remodelling; pronounced epidermal hyperproliferation after treatment with the phorbol ester 12-O-decanoyl-phorbol-13-acetate; disturbed differentiation; prolonged inflammation Mus musculus
Kit 16590 Antibody treatment Reduced mast cell accumulation at the edge of healing wounds Mus musculus
Kl 16591 Knockout Delayed wound closure; reduced collagen deposition in the wounds; Phenotypic similarities with aged skin Mus musculus
Klf10 21847 Knockout Lower wound breaking strength Mus musculus
Klf10 21847 Knockout Delay in wound closure; impaired wound contraction, granulation tissue formation, collagen synthesis, and reepithelialization Mus musculus
Klf4 16600 Knockout Delayed wound healing; decreased accumulation of Myeloid-derived suppressor cells and fibrocytes Mus musculus
Klf4 16600 Knockout Delayed wound healing; decreased stem cell-enriched population Mus musculus
Klk8 259277 Knockout Delayed wound healing; defective keratinocyte proliferation, differentiation, and migration in the early stages of wound healing Mus musculus
Krt6a 16687 Knockout Delay in re-epithelialization only from the hair follicle; healing of wounds was not impaired Mus musculus
Krt76 77055 Knockout Impaired wound healing; neonatal skin flaking; hyperpigmentation, inflammation, and death prior to 12 weeks of age Mus musculus
Lep 16846 Knockout; protein administration; antibody treatment Knockout: Delayed wound healing; mild diabetic phenotype; systemically and topically supplemented leptin improved re-epithelialization of wounds in knockout mice; topically supplemented leptin accelerated normal wound-healing Mus musculus
Lgals1 16852 Knockout Delayed wound healing Mus musculus
Lgals3bp 19039 Knockout Delayed wound healing; reduced collagen expression Mus musculus
Lgals7 16858 Knockout Reduced reepithelialization potential; defect in cell migration Mus musculus
Lpp 210126 Knockout Reduced embryonic fibroblast migration Mus musculus
Lsp1 16985 Knockout Accelerated wound healing and re-epithelialization; increased collagen synthesis and angiogenesis Mus musculus
Lum 17022 Knockout Delayed wound healing; increase in inflammatory macrophages; delayed response of the expression of TGF-β1, type I collagen α1 and fibronectin Mus musculus
Map3k1 26401 siRNA knockdown Delayed wound closure; impaired activation of Jun NH2-terminal kinases, induction of plasminogen activator inhibitor (PAI)-1, and restoration of cell-cell junctions of the wounded epidermis Mus musculus
Map3k5 675366 Knockout Retardation of wounding-induced hair regrowth Mus musculus
Map3k7 666611 Knockout Impaired wound healing; decreased collagen deposition, α-SMA and CCN2 expression Mus musculus
Mapkapk2 17164 Knockout Higher level of acanthosis of the migrating wound keratinocyte layer; higher level of collagen deposition in the granulation tissue Mus musculus
Med1 19014 Knockout Accelerated wound closure and re-epithelialization Mus musculus
Met 17295 Knockout Keratinocytes were unable to contribute to re-epithelialization; wound closure was slightly attenuated, but occurred exclusively by a few (5%) keratinocytes that had escaped recombination Mus musculus
Mfap2 17150 Knockout Altered wound healing response Mus musculus
Mfge8 17304 Knockout Delayed wound healing; reduced myofibroblast and vessel numbers Mus musculus
Mgat5 107895 Overexpression Accelerated wound healing Mus musculus
Mif 100040259 Knockout Delayed wound healing Mus musculus
Mir155 387173 Knockout Accelerated wound closure; elevated numbers of macrophages Mus musculus
Mir21a 387140 Overexpression; antagonist andministration Overexpression of miR-21: stronger wound contraction; antagomiR administration: delay of wound closure with impaired collagen deposition Mus musculus
Mmp13 17386 Knockout Delayed wound healing Mus musculus
Mmp1a 83995 Mutation Delayed wound healing (in mice expressing the human gene in the epidermis) Mus musculus
Mmp3 17392 Knockout Wounds failed to contract and healed more slowly Mus musculus
Mmp8 17394 Knockout Impaired wound healing Mus musculus
Mmp9 17395 Knockout Delayed wound healing; defect in keratinocyte migration Mus musculus
Mrc2 17534 Knockout Delayed re-epithelialization; altered stiffness of the scar tissue; no difference in total collagen content of the wounds Mus musculus
Mstn 17700 Knockout Delayed wound healing; delayed epidermal reepithelialization and dermal contraction Mus musculus
Msx2 17702 Knockout Accelerated wound closure and re-epithelialization; earlier appearance of keratin markers for differentiation and an increased level of smooth muscle actin and tenascin in the granulation tissue Mus musculus
Myb 17863 Knockout Heterozygous c-myb deficiency has a functional effect on wound repair; collagen type I levels and transforming growth factor-beta1 expression are elevated Mus musculus
Myc 17869 Knockout Impaired wound healing Mus musculus
Myd88 17874 Knockout Delayed wound healing; delayed contraction; decreased and delayed granulation tissue formation; reduced new blood vessel density Mus musculus
Ncoa3 17979 Knockout Delayed wound healing Mus musculus
Ncoa6 56406 Knockout Spontaneous natural wounds healing defects Mus musculus
Nf1 18015 Knockout Abnormal pattern and amount of collagen-rich granulation bed tissue; skin wound fibroblasts proliferated past the normal wound maturation phase Mus musculus
Nfe2l2 18024 Knockout Prolonged inflammation in the late phase of repair; reduced expression of various key players in the early phase; Mus musculus
Nfic 18029 Knockout Accelerated wound closure; faster inflammatory stage; increased expression of PDGFA and PDGF-receptor alpha; reduced differentiation of fibroblasts to myofibroblasts Mus musculus
Nid1 18073 Knockout hyperproliferation of the newly formed epidermis with a delay in differentiation at day 10 post injury; considerable alpha-smooth muscle actin staining in the dermis of wounds Mus musculus
Nlrp3 216799 Knockout Delayed re-epithelialization, granulation tissue formation, and angiogenesis Mus musculus
Nos1 18125 Knockout Delayed wound closure Mus musculus
Nos2 18126 Knockout Delayed wound closure Mus musculus
Nos3 18127 Knockout Delayed wound closure Mus musculus
Npy2r 18167 Knockout Delayed wound closure with reduced neovascularization Mus musculus
Nr3c1 14815 Mutation Enlarged granulation tissue with a high fibroblast density; late wounds appeared normal; enhanced ability of fibroblasts to contract collagen Mus musculus
Nr3c1 14815 Overexpression Delayed wound healing; delayed re-epithelialization and formation of granulation tissue; reduced recruitment of granulocytes and macrophages; TGF-β1 and Kgf expression was repressed whereas TGF-β3 was up-regulated Mus musculus
Nr4a1 15370 Knockout; overexpression Delayed wound healing in a dominant negative mutant Mus musculus
Ogfr 72075 Overexpression Delayed wound healing Mus musculus
Oprd1 18386 Knockout Delayed wound healing; severe epidermal hypertrophy at the wound margin Mus musculus
P2ry2 18442 Knockout Increased wound size at day 14 post-wounding; reduction in the expression of Ki67, VEGF, collagen I, fibronectin and α-SMA Mus musculus
Panx1 55991 Knockout Delayed wound healing Mus musculus
Pear1 73182 Knockout Accelerated wound closure Mus musculus
Perp 64058 Knockout Delayed wound healing Mus musculus
Pgf 18654 Knockout Impaired angiogenesis, plasma extravasation and collateral growth Mus musculus
Pik3cg 30955 Mutation Delayed resolution of inflammation in wound healing; increased proliferation and decreased apoptosis Mus musculus
Pkd1 18763 Knockout Delayed wound re-epithelialization; reduced proliferation and migration of keratinocytes at the wound edge Mus musculus
Plaur 18793 Knockout Delayed wound healing Mus musculus
Plec 18810 Knockout Reduced leukocyte infiltration Mus musculus
Plg 18815 Knockout Impaired wound healing Mus musculus
Postn 50706 Knockout Delayed wound healing (rescued by direct administration of exogenous periostin) Mus musculus
Pou2f3 18988 Knockout Various effects on differentiation of epidermal keratinocytes during normal development and wound healing Mus musculus
Pou3f1 18991 Knockout Various effects on differentiation of epidermal keratinocytes during normal development and wound healing Mus musculus
Ppara 19013 Mutation Modulation of early inflammation phase Mus musculus
Ppard 19015 Mutation Impaired adhesion and migration properties Mus musculus
Pparg 19016 Knockout Impaired wound healing with reduced collagen deposition, angiogenesis and granulation formation Mus musculus
Ppp1r15a 17872 Knockout Accelerated wound healing; reduced amounts of myosin IIA in migrating macrophages and myofibroblasts Mus musculus
Prdx6 11758 Knockout Damaged endothelial cells with an enhanced rate of apoptosis; hemorrhage in the granulation tissue Mus musculus
Prkca 18750 Knockout Delayed granulation tissue deposition; failure to upregulate collagen and other ECM components Mus musculus
Prkce 18754 Knockout Delayed wound closure and a reduction in myofibroblasts Mus musculus
Prkch 18755 Knockout Delayed wound healing, particularly re-epithelialization Mus musculus
Pten 19211 Knockout Various effects indicating the importance of mTOR Mus musculus
Ptger3 19218 Knockout Delayed wound closure and re-epithelization; inhibited angiogenesis; reduction in immunoreactive vascular endothelial growth factor (VEGF) in granulation tissues Mus musculus
Ptgs1 19224 Knockout Reduced breaking strength; enhanced angiogenesis; reduced macrophages and myofibroblasts at day 12 Mus musculus
Ptgs2 19225 Knockout Reduced breaking strength; enhanced angiogenesis; reduced macrophages and myofibroblasts at day 12 Mus musculus
Ptk2 14083 Knockout Delayed wound healing; decreased dermal thickness and collagen density Mus musculus
Ptk2b 19229 Knockout Delayed wound closure Mus musculus
Ptk7 71461 Knockout Defective wound repair Mus musculus
Rac1 19353 Knockout Delayed wound closure; reduced collagen production and myofibroblast formation Mus musculus
Rac2 19354 Knockout Reduced wound-related lipid peroxidation Mus musculus
Raf1 110157 Knockout Delayed wound healing Mus musculus
Ramp1 51801 Knockout Suppressed wound healing and wound-induced angiogenesis; reduced expression of vascular endothelial growth factor (VEGF)-A Mus musculus
Reck 631094 Knockout Improved wound healing Mus musculus
Ripk3 56532 Knockout Delayed wound healing Mus musculus
S100a9 20202 Knockout Diminished recruitment of granulocytes into the granulation tissue Mus musculus
Scrib 105782 Knockout Defective wound repair Mus musculus
Sdc1 20969 Knockout Prolonged hypoplasia; delayed cell proliferation and reduced localization of alpha9 integrin in the epidermis Mus musculus
Sdc4 20971 Knockout Delayed wound healing and impaired angiogenesis in the granulation tissue Mus musculus
Sele 20339 Double Knockout Reduced recruitment of inflammatory cells and impaired wound closure in mice deficient in both P- and E-selectins Mus musculus
Sell 20343 Knockout Delayed wound healing Mus musculus
Selp 20344 Double Knockout Reduced recruitment of inflammatory cells and impaired wound closure in mice deficient in both P- and E-selectins Mus musculus
Sept4 18952 Knockout Improvement in wound healing and regeneration of hair follicles Mus musculus
Serpine1 18787 Knockout Accelerated wound closure Mus musculus
Serpinf2 18816 Knockout Accelerated wound closure; increased angiogenesis Mus musculus
Sfpi1 20375 Knockout Accelerated wound healing with reduced fibrosis; incapacity to raise the standard inflammatory response, due to a lack of macrophages and functioning neutrophils Mus musculus
Siah2 20439 Knockout Delayed wound healing; delayed induction of myofibroblast infiltration and reduced collagen deposition; delayed angiogenesis and reduced macrophage infiltration into the wounds Mus musculus
Slc11a1 18173 Knockout Delayed wound healing Mus musculus
Slc6a6 21366 Knockout Delayed wound closure in 12-mo mice; no effect in 5-mo mice Mus musculus
Slpi 20568 Knockout Impaired wound healing with increased inflammation and elastase activity Mus musculus
Smad2 17126 Overexpression Delayed wound healing; a defect in basal keratinocyte migration Mus musculus
Smad3 17127 Knockout Accelerated dorsal wound healing; ear wounds are enlarged resulting from changes in extracellular matrix molecules Mus musculus
Smad4 17128 Knockout Delayed wound closure and remodeling; increased angiogenesis and inflammation Mus musculus
Smad7 17131 Overexpression Accelerated re-epithelialization; increase in keratinocyte proliferation; reduced Smad2 activation; increased activation of extracellular signal-regulated kinase (Erk) Mus musculus
Snai2 20583 Knockout Reduced re-epithelialization; increased expression of the Slug target genes keratin 8 and E-cadherin at wound margins; 40% of mice developed non-healing cutaneous ulcers in response to chronic UVR Mus musculus
Socs3 12702 Overexpression Impaired wound healing; atrophied wound-margin epithelia and augmented response of keratinocytes; a prolonged persistence of neutrophils and macrophages; elevated levels of TGF-beta1 Mus musculus
Sod1 545845 Knockout Delayed wound healing Mus musculus
Sorbs3 20410 Knockout Delay in wound healing in both back and tail, without affecting the proliferation of keratinocytes Mus musculus
Sparc 100046740 Knockout Accelerated wound closure Mus musculus
Sparcl1 13602 Knockout Accelerated wound healing; enhanced macrophage infiltration of wound beds at early time points; earlier appearance of mature extracellular matrix; fibrovascular invasion of polyvinyl alcohol sponges was more robust Mus musculus
Spi1 20375 knockout Scar-free repair; altered growth factor and cytokine profile; cell death is reduced, and dying cells are instead engulfed by stand-in phagocytic fibroblasts Mus musculus
Spp1 20750 Knockout Decreased level of debridement; greater disorganization of matrix; alteration of collagen fibrillogenesis leading to small diameter collagen fibrils; tensile properties of the wounds were unchanged Mus musculus
Stat3 20848 Knockout Compromised wound healing and hair cycle; developed spontaneously occurring ulcers with age Mus musculus
Tcf3 21423 Overexpression Accelerated wound healing and keratinocyte migration Mus musculus
Tert 21752 Overexpression Accelerated wound healing Mus musculus
Tgfa 21802 Knockout Ear model: delayed re-epithelialization; Head model: no difference in epithelial gap or new granulation tissue Mus musculus
Tgfb1 21803 Knockout Decreased granulation tissue formation, vascularity, collagen deposition, epithelialization and a marked inflammatory infiltrate Mus musculus
Tgfb3 21809 Protein administration Scar-free wound healing in adults Mus musculus
Tgfbr2 21813 Knockout Accelerated wound closure and re-epithelization; reduced collagen deposition and remodeling; reduced extent of wound contraction, and elevated macrophage infiltration Mus musculus
Tgm1 21816 Knockout Delayed wound healing Mus musculus
Thbd 21824 Overexpression Delayed wound healing; reduced granulation tissue formation and highly diminished wound angiogenesis Mus musculus
Thbd 21824 Knockout Delayed wound healing Mus musculus
Thbs1 21825 Overexpression Delayed wound healing; reduced granulation tissue formation and highly diminished wound angiogenesis Mus musculus
Thbs2 21826 Knockout Improved wound healing Mus musculus
Thra 100047427 Knockout Delayed re-epithelialization and wound closure; impaired keratinocyte proliferation Mus musculus
Thrb 21834 Knockout Delayed re-epithelialization and wound closure; impaired keratinocyte proliferation Mus musculus
Thy1 21838 siRNA treatment Impaired wound healing; the level of TGF-β1 at the wound continuously increased Mus musculus
Timp1 21857 Knockout Delayed wound healing with slow migration of keratinocytes over the wound Mus musculus
Tlr2 24088 Knockout Delayed wound healing; decreased numbers of infiltrating macrophages in the dermis and decreased TGF-β and CCL5 mRNA expression Mus musculus
Tlr4 21898 Knockout Delayed wound healing; decreased numbers of infiltrating macrophages in the dermis and decreased TGF-β and CCL5 mRNA expression Mus musculus
Tlr9 81897 Knockout Delayed wound healing Mus musculus
Tnf 21926 Knockout Promotion of granulation tissue formation and delayed re-epithelialization Mus musculus
Tnfrsf1a 21937 Knockout Accelerated wound healing; enhanced angiogenesis and collagen content; accelerated re-epithelialization with increased gene expression of TGF-beta1, CTGF, VEGF, Flt-1, and Flk-1 Mus musculus
Tnfsf14 50930 Knockout Impaired wound healing with characteristics of nonchronic and chronic ulcers Mus musculus
Tnxb 81877 Knockout Reduced breaking strength of unwounded skin; after wounding, scars do not progress beyond the mechanical strength of uninjured skin; no obvious differences in the rate of wound closure Mus musculus
Tpm3 236479 Deletion of exon Accelerated wound healing; increased cell migration Mus musculus
Trp53 22059 Mutation Delayed wound closure Mus musculus
Trpc6 22068 Knockout Impaired wound healing Mus musculus
Tsc1 64930 Knockout Accelerated wound healing Mus musculus
Tsk2 109631 Knockout Delayed wound healing Mus musculus
Vangl2 93840 Knockout; Double Knockout Defective wound repair Mus musculus
Vav1 22324 Knockout Delayed wound healing Mus musculus
Vav3 57257 Knockout Delayed wound healing Mus musculus
Vegfa 22339 Overexpression; inhibitor administration Promotion of lymphangiogenesis; systemic blockade of VEGFR-2 prevented lymphatic vessel formation Mus musculus
Vegfa 22339 Overexpression Rapid wound closure Mus musculus
Vegfa 22339 Protein administration Improved wound healing by locally up-regulating growth factors important for tissue repair and by systemically mobilizing bone marrow-derived cells Mus musculus
Vim 22352 Knockout Delayed wound contraction, migration of fibroblasts into the wound site, and appearance of myofibroblasts at the wound site Mus musculus
Vtn 22370 Knockout Delayed wound healing; extensive areas of delayed hemorrhage near the sprouting tips of microvessels between days 7 and 14 Mus musculus
Wfdc1 67866 Knockout Accelerated wound closure; elevated deposition of osteopontin and macrophage recruitment Mus musculus
F2 29251 Peptide administration Accelerated wound closure in both normal and ischemic skin Rattus norvegicus
Adm 25026 Protein administration Accelerated wound closure Rattus norvegicus
Adrb1 24925 Antagonist administration Delayed contraction in propranolol- and atenolol-treated animals but not in phentolamine-treated animals; re-epithelialization was decreased only in propranolol-treated animals Rattus norvegicus
Adrb2 24176 Antagonist administration Delayed contraction in propranolol- and atenolol-treated animals but not in phentolamine-treated animals; re-epithelialization was decreased only in propranolol-treated animals Rattus norvegicus
Agt 24179 Protein administration Accelerated wound closure Rattus norvegicus
Ankrd1 27064 Overexpression Increased vascular component in granulation tissue Rattus norvegicus
C3 24232 Protein administration Increased maximal breaking strength; increased fibroblast and collagen deposition; additive hemostatic effect with the C3C5 combination Rattus norvegicus
C5 362119 Protein administration Increased maximal breaking strength; increased fibroblast and collagen deposition; additive hemostatic effect with the C3C5 combination Rattus norvegicus
C5 362119 Protein administration Increased maximal breaking strength; accelerated wound healing; increased vascular permeability, increased inflammatory cell recruitment, subsequent fibroblast migration, and increased collagen deposition Rattus norvegicus
Cfh 155012 Protein administration Accelerated wound closure Rattus norvegicus
Egf 25313 Protein administration Accelerated wound closure; Accelerated epidermal proliferation Rattus norvegicus
Egf 25313 Protein administration Promotion of wound healing Rattus norvegicus
Egf 25313 Overexpression Flap survival was enhanced by 14%, and was accomplished without accessing the arterial inflow of the territory Rattus norvegicus
Egf 25313 Protein administration Accelerated re-repithelialization Rattus norvegicus
Epo 24335 Protein administration, antibody treatment Protein administration: Increased granulation tissue formationr; Receptor or neutralizing antibody administration: inhibited granulation tissue formation Rattus norvegicus
Epor 24336 Protein administration, antibody treatment Protein administration: Increased granulation tissue formationr; Receptor or neutralizing antibody administration: inhibited granulation tissue formation Rattus norvegicus
Fgf10 25443 Protein administration Accelerated re-epithelialization in the meshed skin graft model; more rapid gain in breaking strength of surgical incisions Rattus norvegicus
Fgf2 54250 Antibody treatment Reduced collagen content Rattus norvegicus
Fgf2 54250 Protein administration Increased α-SMA up to day 18 and then caused a decrease Rattus norvegicus
Fgf7 29348 Overexpression (liposomal gene transfer) Increased re-epithelialization; improved dermal regeneration; increased neovascularization Rattus norvegicus
Hgf 24446 Protein administration Accelerated re-epithelialization in diabetic rats; increased expressions of the cell adhesion molecules β1-integrin and the cytoskeleton remodeling protein integrin-linked kinase (ILK) in epidermal cells Rattus norvegicus
Hpse 64537 Protein administration Accelerated wound healing and improved FLAP survival; enhanced wound re-epithelialization and blood vessel maturation Rattus norvegicus
Igf1 24482 Overexpression (liposomal gene transfer) Improved dermal regeneration by an increased collagen deposition and morphology; increased VEGF concentrations and neovascularization Rattus norvegicus
Igf1 24482 Overexpression (in exogenous fibroblasts) More organised granulation tissue formation; increased number of keratinocytes Rattus norvegicus
Itgb2 309684 Antibody treatment Improved flap survival; decreased dermal and anastomotic myeloperoxidase activity Rattus norvegicus
Lama3 307582 Peptide administration Accelerated re-epithelialization; reduced inflammatory cell infiltration; enhanced fibroblast proliferation Rattus norvegicus
Lep 25608 Protein administration Increased granulation tissue; improved angiogenesis; better flap survival Rattus norvegicus
Lox 24914 Gene activated matrix Enhanced mechanical strength of the wound site Rattus norvegicus
Mmp8 63849 Overexpression Impaired wound healing by decreased collagen deposition and breaking strength; decreased number of neutrophils Rattus norvegicus
Pdgfb 24628 Protein administration Accelerated wound healing; Accelerated degradation of the polymer and enhanced formation of new granulation tissue as early as day 3 Rattus norvegicus
Proc 25268 Protein administration Enhanced wound healing Rattus norvegicus
Tgfb1 59086 Antibody treatment, protein administration Neutralising TGF-beta 1: reduced the monocyte and macrophage profile, neovascularisation, fibronectin, collagen III and collagen I deposition in the early stages of wound healing; improved the architecture of the neodermis to resemble that of normal dermis and reduced scarring; effect was stronger when comined with TG-beta 2 neutralization; Protein treatment: more extracellular matrix deposition in the early stages of wound healing but did not differ from control wounds in the final quality of scarring Rattus norvegicus
Tgfb1 59086 Protein administration Accelerated wound healing; Increased wound breaking strength; increased influx of mononuclear cells and fibroblasts; increases in collagen deposition Rattus norvegicus
Ngf 310738 Protein administration Accelerated wound healing, re-epithelialization, formation of granulation tissue, and collagen production Rattus norvegicus
Tgfb2 81809 Antibody treatment, protein administration Neutralising TGF-beta 2 alone had no effect; combined with TGF-beta 1, it reduced the monocyte and macrophage profile, neovascularisation, fibronectin, collagen III and collagen I deposition in the early stages of wound healing; markedly improved the architecture of the neodermis to resemble that of normal dermis and reduced scarring; by contrast, wounds treated with either TGF-beta 1 or with TGF-beta 2 had more extracellular matrix deposition in the early stages of wound healing but did not differ from control wounds in the final quality of scarring Rattus norvegicus
Tgfb3 25717 Protein administration Reduced the monocyte and macrophage profile, fibronectin, collagen I and collagen III deposition in the early stages of wound healing and improved the architecture of the neodermis and reduced scarring Rattus norvegicus
Tgfbr2 81810 Overexpression Inhibited inflammatory reaction with reduced inflammatory cells; reduced scarring area Rattus norvegicus
Tmsb4x 81814 protein dimer administration Accelerated wound healing Rattus norvegicus
Vegfa 83785 Overexpression (local plasmid injection) Increased skin flap perfusion; increase in skin flap healing and survival Rattus norvegicus
CALR 100381266 Protein administration Accelerated wound healing; increase in epithelial migration and granulation tissue formation; marked proliferation of basal keratinocytes and dermal fibroblasts; dense cellularity of the dermis with notably increased numbers of macrophages and well-organized collagen fibril deposition Sus scrofa domesticus
APCS 396921 local depletion by ionized agarose gel Accelerated wound healing Sus scrofa domesticus
EGF 397083 Protein administration Accelerated re-epithelialization Sus scrofa domesticus
EGF 397083 Protein administration Accelerated wound closure; improved wound healing quality in terms of number of arranged microvasculature, fibroblast migration and proliferation, collagen deposition and evolution of the inflammatory response Sus scrofa domesticus
EGF 397083 Overexpression (Adenoviral transfection) Promotion of resurfacing; enhanced wound maturity Sus scrofa domesticus
ERBB3 100126862 Overexpression (Adenoviral transfection) Promotion of resurfacing; enhanced wound maturity Sus scrofa domesticus
FGF2 397643 Protein administration Better reconstruction quality in terms of hardness and the function of the stratum corneum Sus scrofa domesticus
GJA1 397259 Peptide administration Decreased scar progenitor tissue area; promoted restoration of dermal histoarchitecture and mechanical strength; reduction in inflammatory neutrophil infiltration Sus scrofa domesticus
HSP90AA1 397028 Peptide administration Accelerated wound healing; accelerated re-epithelialization Sus scrofa domesticus
LTF 397649 Protein administration Accelerated re-epithelialization; increased keratinocyte proliferation and migration Sus scrofa domesticus
NRG3 100158106 Overexpression (Adenoviral transfection) Promotion of resurfacing; enhanced wound maturity Sus scrofa domesticus
VTN 397192 Protein administration Accelerated re-epithelialization; improved morphological features such as wound contraction, scar profile, and hair follicle density Sus scrofa domesticus
PDGFB 5155 Protein administration Greater healing response; no toxic effects Homo sapiens
TGFB3 7043 Protein administration Improved total scar scores; less abnormal orientation of collagen fibres in the reticular dermis Homo sapiens
TGFB3 7043 Various Various; Improved quality of scar tissue Homo sapiens
VEGFA 7422 Overexpression (intramuscular gene transfer) Nonhealing ulcers healed better; improved blood flow with newly visible collateral vessels; adverse consequences were limited to transient ankle or calf edema Homo sapiens
CSF2 1437 Protein administration Elevated number of healed wounds; minor side-effects; none of the treated ulcers recurred after 6 months Homo sapiens
EGF 1950 Protein administration Reduction in ulcer size and a larger number of healed ulcers; failed to enhance re-epithelialization; no side effects Homo sapiens
EGF 1950 Protein administration Accelerated epidermal regeneration Homo sapiens
F13A1 2162 Protein administration Improved wound healing; improved granulation tendency; reduction of secretion and bleeding tendency within the ulcer area Homo sapiens
FGF10 2255 Protein administration Accelerated wound healing, with more patients achieving wound closure Homo sapiens
FGF2 2247 Protein administration Improved wound healing; increased fibroblasts and capillaries; more patients achieved > 70% wound closure Homo sapiens
GJA1 2697 Peptide administration Reduction in ulcer area; accelerated re-epithelialization Homo sapiens
PDGFB 5155 Protein administration Improved wound healing in the feet of diabetics when used in conjunction with standard wound healing practices Homo sapiens
PDGFB 5155 Protein administration After 6 months of topical administration, sufficient granulation tissue developed within the dermal wound; a split-thickness skin graft was successfully performed; wound transformed from a chronic state to a short-term healing state Homo sapiens
PDGFB 5155 Protein administration rhPDGF was more effective than standard therapy in both helping a wound to heal and preventing amputation; the effect was similar to the efficacy estimated from previously published randomized controlled trials Homo sapiens
Contact: Vadim E. Fraifeld, MD, PhD
Head: Lab for the Biology of Aging, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev
P.O. Box 653, Beer-Sheva 8410501, Israel
Email:
How to cite us:
If you would like to cite this database please use:
Yanai H, Budovsky A, Tacutu R, Barzilay T, Abramovich A, Ziesche R, Fraifeld VE. Tissue repair genes: the TiRe database and its implication for skin wound healing. Oncotarget. 2016; 7:21145-55.