Browse Rattus norvegicus genes (39)


Gene symbol Entrez ID Intervention Effect on wound healing
Adm 25026 Protein administration Accelerated wound closure
Adrb1 24925 Antagonist administration Delayed contraction in propranolol- and atenolol-treated animals but not in phentolamine-treated animals; re-epithelialization was decreased only in propranolol-treated animals
Adrb2 24176 Antagonist administration Delayed contraction in propranolol- and atenolol-treated animals but not in phentolamine-treated animals; re-epithelialization was decreased only in propranolol-treated animals
Agt 24179 Protein administration Accelerated wound closure
Ankrd1 27064 Overexpression Increased vascular component in granulation tissue
C3 24232 Protein administration Increased maximal breaking strength; increased fibroblast and collagen deposition; additive hemostatic effect with the C3C5 combination
C5 362119 Protein administration Increased maximal breaking strength; increased fibroblast and collagen deposition; additive hemostatic effect with the C3C5 combination
C5 362119 Protein administration Increased maximal breaking strength; accelerated wound healing; increased vascular permeability, increased inflammatory cell recruitment, subsequent fibroblast migration, and increased collagen deposition
Cfh 155012 Protein administration Accelerated wound closure
Egf 25313 Protein administration Accelerated wound closure; Accelerated epidermal proliferation
Egf 25313 Protein administration Promotion of wound healing
Egf 25313 Overexpression Flap survival was enhanced by 14%, and was accomplished without accessing the arterial inflow of the territory
Egf 25313 Protein administration Accelerated re-repithelialization
Epo 24335 Protein administration, antibody treatment Protein administration: Increased granulation tissue formationr; Receptor or neutralizing antibody administration: inhibited granulation tissue formation
Epor 24336 Protein administration, antibody treatment Protein administration: Increased granulation tissue formationr; Receptor or neutralizing antibody administration: inhibited granulation tissue formation
F2 29251 Peptide administration Accelerated wound closure in both normal and ischemic skin
Fgf10 25443 Protein administration Accelerated re-epithelialization in the meshed skin graft model; more rapid gain in breaking strength of surgical incisions
Fgf2 54250 Antibody treatment Reduced collagen content
Fgf2 54250 Protein administration Increased α-SMA up to day 18 and then caused a decrease
Fgf7 29348 Overexpression (liposomal gene transfer) Increased re-epithelialization; improved dermal regeneration; increased neovascularization
Hgf 24446 Protein administration Accelerated re-epithelialization in diabetic rats; increased expressions of the cell adhesion molecules β1-integrin and the cytoskeleton remodeling protein integrin-linked kinase (ILK) in epidermal cells
Hpse 64537 Protein administration Accelerated wound healing and improved FLAP survival; enhanced wound re-epithelialization and blood vessel maturation
Igf1 24482 Overexpression (liposomal gene transfer) Improved dermal regeneration by an increased collagen deposition and morphology; increased VEGF concentrations and neovascularization
Igf1 24482 Overexpression (in exogenous fibroblasts) More organised granulation tissue formation; increased number of keratinocytes
Itgb2 309684 Antibody treatment Improved flap survival; decreased dermal and anastomotic myeloperoxidase activity
Lama3 307582 Peptide administration Accelerated re-epithelialization; reduced inflammatory cell infiltration; enhanced fibroblast proliferation
Lep 25608 Protein administration Increased granulation tissue; improved angiogenesis; better flap survival
Lox 24914 Gene activated matrix Enhanced mechanical strength of the wound site
Mmp8 63849 Overexpression Impaired wound healing by decreased collagen deposition and breaking strength; decreased number of neutrophils
Ngf 310738 Protein administration Accelerated wound healing, re-epithelialization, formation of granulation tissue, and collagen production
Pdgfb 24628 Protein administration Accelerated wound healing; Accelerated degradation of the polymer and enhanced formation of new granulation tissue as early as day 3
Proc 25268 Protein administration Enhanced wound healing
Tgfb1 59086 Antibody treatment, protein administration Neutralising TGF-beta 1: reduced the monocyte and macrophage profile, neovascularisation, fibronectin, collagen III and collagen I deposition in the early stages of wound healing; improved the architecture of the neodermis to resemble that of normal dermis and reduced scarring; effect was stronger when comined with TG-beta 2 neutralization; Protein treatment: more extracellular matrix deposition in the early stages of wound healing but did not differ from control wounds in the final quality of scarring
Tgfb1 59086 Protein administration Accelerated wound healing; Increased wound breaking strength; increased influx of mononuclear cells and fibroblasts; increases in collagen deposition
Tgfb2 81809 Antibody treatment, protein administration Neutralising TGF-beta 2 alone had no effect; combined with TGF-beta 1, it reduced the monocyte and macrophage profile, neovascularisation, fibronectin, collagen III and collagen I deposition in the early stages of wound healing; markedly improved the architecture of the neodermis to resemble that of normal dermis and reduced scarring; by contrast, wounds treated with either TGF-beta 1 or with TGF-beta 2 had more extracellular matrix deposition in the early stages of wound healing but did not differ from control wounds in the final quality of scarring
Tgfb3 25717 Protein administration Reduced the monocyte and macrophage profile, fibronectin, collagen I and collagen III deposition in the early stages of wound healing and improved the architecture of the neodermis and reduced scarring
Tgfbr2 81810 Overexpression Inhibited inflammatory reaction with reduced inflammatory cells; reduced scarring area
Tmsb4x 81814 protein dimer administration Accelerated wound healing
Vegfa 83785 Overexpression (local plasmid injection) Increased skin flap perfusion; increase in skin flap healing and survival

Contact: Vadim E. Fraifeld, MD, PhD
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