Browse Homo sapiens genes (14)


Gene symbol Entrez ID Intervention Effect on wound healing
CSF2 1437 Protein administration Elevated number of healed wounds; minor side-effects; none of the treated ulcers recurred after 6 months
EGF 1950 Protein administration Reduction in ulcer size and a larger number of healed ulcers; failed to enhance re-epithelialization; no side effects
EGF 1950 Protein administration Accelerated epidermal regeneration
F13A1 2162 Protein administration Improved wound healing; improved granulation tendency; reduction of secretion and bleeding tendency within the ulcer area
FGF10 2255 Protein administration Accelerated wound healing, with more patients achieving wound closure
FGF2 2247 Protein administration Improved wound healing; increased fibroblasts and capillaries; more patients achieved > 70% wound closure
GJA1 2697 Peptide administration Reduction in ulcer area; accelerated re-epithelialization
PDGFB 5155 Protein administration Improved wound healing in the feet of diabetics when used in conjunction with standard wound healing practices
PDGFB 5155 Protein administration After 6 months of topical administration, sufficient granulation tissue developed within the dermal wound; a split-thickness skin graft was successfully performed; wound transformed from a chronic state to a short-term healing state
PDGFB 5155 Protein administration rhPDGF was more effective than standard therapy in both helping a wound to heal and preventing amputation; the effect was similar to the efficacy estimated from previously published randomized controlled trials
PDGFB 5155 Protein administration Greater healing response; no toxic effects
TGFB3 7043 Various Various; Improved quality of scar tissue
TGFB3 7043 Protein administration Improved total scar scores; less abnormal orientation of collagen fibres in the reticular dermis
VEGFA 7422 Overexpression (intramuscular gene transfer) Nonhealing ulcers healed better; improved blood flow with newly visible collateral vessels; adverse consequences were limited to transient ankle or calf edema
Contact: Vadim E. Fraifeld, MD, PhD
Head: Lab for the Biology of Aging, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev
P.O. Box 653, Beer-Sheva 8410501, Israel
Email:
How to cite us:
If you would like to cite this database please use:
Yanai H, Budovsky A, Tacutu R, Barzilay T, Abramovich A, Ziesche R, Fraifeld VE. Tissue repair genes: the TiRe database and its implication for skin wound healing. Oncotarget. 2016; 7:21145-55.