Browse Mus musculus genes (318)


Gene symbol Entrez ID Intervention Effect on wound healing
Acvr1b 11479 Overexpression of a dominant negative Delayed re-epithelialization
Adam9 11502 Knockout Accelerated re-epithelialization and wound repair
Adamts1 11504 Knockout Delayed wound closure and increased angiogenic response
Adamts1 11504 Knockout Keratinocyte differentiation abnormalities
Adamts5 632263 Knockout Impaired contraction and dermal collagen deposition
Adipoq 11450 Knockout; protein administration Delay in wound closure; impaired keratinocyte proliferation and migration
Adora2a 11540 Knockout; agonist administration Knockout: delayed the course of skin wound healing; agonist: promoted the course of skin wound healing
Adra2a 11551 Knockout Accelerated wound contraction and re-epithelialization
Adra2c 11553 Knockout Accelerated wound contraction and re-epithelialization
Adrb2 11555 Knockout; antagonist administration Promotion of wound repair; increased angiogenesis, dermal fibroblast function and re-epithelialization; no effect on wound inflammation
Aebp1 11568 Knockout Deficient wound healing
Agtr1a 11607 Knockout; antagonist administration Suppressed wound healing and angiogenesis; delayed wound healing after antagonist administration
Ahr 11622 Knockout; antisense silencing Accelerated re-epithelialization; increased keratinocyte migration; increased collagen content in the granulation tissue
Aimp1 13722 Knockout; protein administration Knockout: delayed wound healing; Protein administration: stimulated dermal fibroblast proliferation, collagen production, and wound closure
Akt1 100047666 Knockout Impaired assembly of collagen in skin wounds and around the blood vessels; reduced vascular area and impaired vascular maturation; lower expression of VEGF; no significant difference in migration of fibroblasts into the wound area was observed and the dynamics of wound closure were similar
Alox5 11689 Knockout Accelerated wound healing with an upregulation of heme oxygenase-1 (HO-1)
Angpt1 11600 Overexpression Under nondiabetic conditions, combining Ang1 and VEGF overexpression resulted in accelerated wound closure
Angptl4 57875 Knockout; siRNA knockdown; antibody treatment Delayed wound reepithelialization with impaired keratinocyte migration; diminished integrin-mediated signaling
Angptl6 70726 Knockout Accelerated wound closure; thickened epidermis and a marked increase in proliferating epidermal cells as well as vascular cells
Ankrd1 107765 Knockout Extensive necrosis of ischemic skin flaps and delayed wound closure; decreased contraction and reduced granulation tissue thickness
Anpep 16790 Antibody treatment Accelerated wound closure; increase of collagen deposition and fibroblast contractility in the granulation tissue
Anxa1 16952 Knockout Delayed wound healing; impaired endothelial cell sprouting
Aqp3 11828 Knockout Delayed wound healing
Ar 11835 Knockout Accelerated wound healing; enhanced inflammatory response through a localized increase in TNF-alpha expression; no acceleration in keratinocyte- and fibroblast-specific knockouts
Arhgap1 667205 Knockout Delayed re-epithelialization in the wound edge 4 days after wounding
Arnt 11863 Knockout Deficient infiltration of cells during the early phases of wound healing; neoangiogenic deficiencies alongside a reduction in numbers of proangiogenic progenitor cells from bone marrow and peripheral blood samples
Arnt 11863 Knockdown Delayed wound healing
Arrb2 216869 Knockout Accelerated wound re-epithelialization
Asprv1 67855 Overexpression Delayed wound healing
B4galt1 14595 Knockout Delayed wound healing; reduced re-epithelialization, collagen synthesis, and angiogenesis; impaired recruitment of neutrophils and macrophages
Bcl11b 58208 Knockout Defects in proliferation and migration of keratinocytes during re-epithelialization; Reduced epidermal proliferation; delayed keratinocyte activation; altered cell-cell adhesion and impaired ECM development; Post wounding: lack of E-Cadherin suppression in the migratory tongue; insufficient expression of alpha smooth muscle actin (α-SMA) in the dermis; robust induction of K8; dysregulated expression of several hair follicle (HF) stem cell markers
Bmp6 12161 Overexpression Delayed re-epitheliazation
Bmx 12169 Overexpression Accelerated re-epithelialization and keratinocyte proliferation; chronic inflammation and angiogenesis in the skin
Bub1b 12236 Hypermorphic mutation Delayed wound healing
C1qa 12259 Knockout Defective blood vessel formation
C3 12266 Knockout Accelerated early stages of wound healing; reduction in inflammatory infiltrate; increased accumulation of mast cells and advanced angiogenesis
C5ar1 12273 Knockout Accelerated early stages of wound healing; reduction in inflammatory infiltrate; increased accumulation of mast cells and advanced angiogenesis
Cadm1 54725 Knockout; overexpression Both knockout and overexpression led to a markedly delayed wound healing
Calca 12310 Knockout; antagonist administration Suppressed angiogenesis and wound closure; reduction in expressions of vascular endothelial growth factor (VEGF) in the wound granulation tissues; Antagonist administration (when infused with mini-osmotic pumps) subcutaneously blocked the wound healing processes and reduced the expressions of CD31 and VEGF expression in the wound granulation tissues
Cap2 67252 Knockout Altered wound healing response presumably resulting from reduced levels of α-SMA; decreased macrophage infiltration and slower neovascularization
Car8 676792 Overexpression Induction of neovascularization
Casp1 100044207 Knockout Delayed re-epithelialization, granulation tissue formation, and angiogenesis
Cast 12380 Overexpression Delay in wound healing, particularly in the initial steps; reduced proliferation in the epidermis and delayed re-epithelization; impaired granulation tissue formation; reduction in CD45+ leukocyte infiltrate and in CD31+ blood vessel density; reduction in α-SMA expressing myofibroblasts
Cav1 12389 Knockout Accelerated wound healing; increased NO production; increased MMP-13 nitration
Ccl17 20295 Overexpression Accelerated wound closure; increase in CCR4(+) fibroblasts, CCR4(+) lymphocytes, NGF(+) lymphocytes, and mast cells
Ccl2 20296 Knockout Delayed wound re-epithelialization and angiogenesis; collagen synthesis was impeded with wounds containing significantly less hydroxyproline; no change in the number of wound macrophages
Cd109 235505 Overexpression Hypoxic wounds in both transgenic and wild-type mice increased levels of HIF-1α and delayed wound closure; Hypoxic wounds in transgenic mice decreased collagen type 1 and fibronectin expression and reduced dermal thickness on day 7 post-wounding
Cd151 12476 Knockout Defective wound healing
Cd19 12478 Knockout; overexpression Knockout: delayed wound healing and inhibition in infiltration of neutrophils, macrophages, and cytokine expression; Overexpression: enhanced wound healing and cytokine expression
Cd24a 12484 Knockout; overexpression Knockout: delay in the formation of granulation tissue and wound closure; failure to maintain stitches; Overexpression: improvemment in healing
Cd44 12505 Knockout Decrease in skin elasticity; impaired local inflammatory response and tissue repair; delayed hair regrowth
Cd47 16423 Knockout Accelerated wound closure; increased blood flow; increased fibrosis
Cd9 12527 Knockout Delayed wound healing and defective re-epithelialization
Cdkn1b 12576 Mutation Delayed wound closure by defective regrowth of epithelial cells
Ceacam1 26367 Knockout Delayed re-epithelialization; decreased infiltration of F4/80(+) macrophages; altered inflammatory processes; diminished vascular density of the granulation tissue
Cebpg 12611 siRNA knockdown Impaired wound healing; inhibition of both re-epithelialization and granulation tissue formation; decrease of arteriole number
Celsr1 12614 Knockout Defective embryonic wound repair
Cftr 12638 Knockout Delayed wound healing
Chrm3 12671 Knockout Accelerated epithelialization
Chrm4 12672 Knockout Delayed re-epithelialization
Clec3b 21922 Knockout Delayed wound healing
Clic4 29876 Knockout Delayed re-epithelialization; delayed resolution of inflammation
Cmah 12763 Knockout Delayed wound healing
Col18a1 12822 Knockout; overexpression Overexpression: delayed wound healing; Knockdown: accelerated wound healing and accelerated vascularisation
Col1a1 12842 Mutation Delayed wound healing and re-epithelialization; prolonged early inflammatory response
Col7a1 12836 Knockout Defects in dermal fibroblast migration and cytokine production in the granulation tissue; perturbation of laminin-332 organization during wound healing; strictly polarized expression of integrin α6β4 in basal keratinocytes
Csf2 12981 Knockout; overexpression Knockout: Delayed wound healing; overexpression (in the basal layer of the epidermis): accelerated re-epithelialization
Ctnnb1 12387 Knockout Affected the TGF-beta wound healing response
Ctsg 13035 Knockout Decrease in wound-breaking strength; increase in neutrophil myeloperoxidase activity and influx
Cx3cl1 20312 Knockout; antibody treatment Delayed wound closure; reduced α-SMA and collagen deposition; reduced neovascularization
Cxcl10 100045000 Overexpression Prolonged and disorganized granulation phase with impaired blood vessel formation; intensified inflammatory phase
Cxcl11 56066 Knockout Delayed re-epithelialization; hypercellular and immature dermis noted even after 60 days; provisional matrix components persisted in the dermis, and the mature basement membrane components laminin V and collagen IV were severely diminished
Cxcr2 12765 Knockout Delay in re-epithelialization and decreased neovascularization
Cxcr3 12766 Knockout Thick keratinized scar with a thickening of both the epidermis and dermis; the dermis was disorganized with thick and long collagen fibrils and contained excessive collagen content; Pesented lower tensile/burst strength
Cxxc5 67393 Knockout Accelerated wound healing; enhanced keratin 14 and collagen synthesis
Cyr61 16007 Mutation Exacerbated fibrosis
Dact2 240025 Knockout Accelerated re-epithelialization
Ddr2 18214 Knockout Reduced proliferative response
Dmd 13405 Knockout Accelerated wound closure
Dst 13518 Knockout Delayed wound healing
E2f1 13555 Knockout Delayed re-epithelialization; reduced local inflammatory responses
Edil3 13612 Overexpression Normal wound healing; increased rate of hair regrowth
Edn1 13614 Double overexpression Accelerated wound closure; increased fibrogenesis; excessive scarring
Edn1 13614 Knockout Accelerated wound healing, indicated by earlier granulation tissue reduction and re-epithelialization; bleomycin-injected fibrotic skin showed decreased skin thickness and collagen content
Egfr 13649 Knockout Modified both normal and wound-induced epidermal proliferation
Egln1 112405 Knockout Accelerated wound closure
Egr1 13653 Knockout; overexpression Knockout: Impaired wound healing; overexpression: exuberant tissue repair, with enhanced collagen accumulation and increased tensile strength of incisional wounds
Eif3e 16341 siRNA treatment Accelerated wound closure; promoted neoangiogenesis in the area surrounding the injury, including in genetically diabetic mice
Eng 13805 Knockout Delay in wound healing; keratinocytes at the wound edges exhibited impaired proliferation but were more migratory
Epas1 13819 Knockout Accelerated wound closure; reduced inflammatory response
Epb41 269587 Knockout Defective epidermal wound healing; impaired cell adhesion, spreading, migration and motility in keratinocyts
Epo 13856 Protein administration Single-high-dose treatment accelerated wound epithelialization and induced maturation of newly formed microvascular networks. In contrast, repeated-high-dose impaired the healing process, delayed re-epithelialization with a lack of maturation of microvascular networks
Eppk1 223650 Knockout Rapid wound closure
Ereg 13874 Protein administration Greater epidermal proliferation and thickening
Esr1 13982 various Various
F13a1 74145 Knockout Impaired wound healing
F7 14068 Knockout Defective re-epithelialization and reduced inflammatory cell infiltration
F9 14071 Knockout Impaired wound healing
Fam129b 227737 Knockout Delayed wound healing
Fga 14161 Knockout Altered pattern of epithelial cell migration and increased epithelial hyperplasia; granulation tissue failed to adequately close the wound gap, resulting in persistent open wounds or partially covered sinus tracts; reduced tensile strength
Fgf2 14173 Knockout Delayed wound healing
Fgfr1 14182 Knockout Delayed wound healing; impaired wound contraction and a delay in re-epithelialization
Fgfr1op2 675026 Overexpression Accelerated wound closure; limited granulation tissue formation
Fgfr2 14183 Knockout Delayed reepithelialization; abnormalities in the hair follicles; dermal hyperthickening
Fgfr2 14183 Knockout Delayed wound healing and re-epithelialization; impaired wound contraction
Fhl2 14200 Knockout Impaired collagen contraction and cell migration; reduced expression of α-SMA
Flii 100044937 Knockout; antibody treatment Intradermal injection of Flii-neutralizing antibodies to burn wounds improved their healing; Knockout: TGF-beta1 protein and gene expression were reduced while aTGF-beta3 was elevated; decreased anti-α-SMA
Flna 192176 Knockout Delayed wound healing
Fmod 14264 Knockout Delayed wound closure and significantly increased scar size
Fn1 14268 Mutation Abnormal wound healing
Fntb 639541 Knockout Delayed wound healing
Foxo1 56458 Knockout Accelerated wound healing with enhanced keratinocyte migration; reduced granulation tissue formation; decreased collagen density; attenuated inflammatory response (only in heterozygous knockout)
Foxo3 56484 Knockout Accelerated wound healing
Fpr1 14293 Double Knockout Delayed wound healing in double KO; no effect in single KO
Fpr2 14289 Double Knockout Delayed wound healing in double KO; no effect in single KO
Fst 14313 Knockout Delayed wound healing; reduced granulation tissue formation; reduction in wound breaking strength; smaller scar area
Gja1 14609 Knockout Accelerated wound closure
Gjb3 14620 Mutation Accelerated wound healing
Gpr39 71111 Knockout Delayed wound healing during the intermediate stage
Grhl3 230824 Knockout Deficient wound repair and defective skin barrier function
H2-Eb1 14969 Knockout Impaired wound collagen deposition and breaking strength; diminished mitogen-reactivity of splenic T-cells
Has1 15116 Overexpression Promotion of dermal regeneration; decreased inflammatory response; recapitulation of fetal extracellular matrix HMW-HA content
Hbegf 15200 Knockout Impaired wound closure
Hdc 15186 Knockout; overexpression Knockout: Delayed wound healing; Overexpression: accelerated wound healing
Hgf 15234 Overexpression Increased granulation tissue with marked vascularization
Hif1a 15251 Knockout Accelerated wound closure and re-epithelialization
Hif1a 15251 Knockout Impaired wound closure and revascularization of ischemic tissue
Hmmr 15366 Knockout Aberrant granulation tissue; defective activation of fibroblast migration/differentiation
Hmox1 15368 Knockout; overexpression; inhibitor administration Inhibition and knockout: delayed wound closure; Overexpression: accelerated wound closure and improved neovascularization
Hmox2 15369 Knockout Delayed wound closure; reduced collagen deposition and vessel density
Hoxa3 15400 Overexpression Acceleration of diabetic wound closure
Hoxb13 15408 Knockout; overexpression Enhanced wound healing and high levels of hyaluronan; reduced long-term scarring
Hoxd3 15434 Overexpression Acceleration of diabetic wound closure
Hpse 15442 Antibody treatment Improved wound healing
Hspb1 15507 Knockout Delayed wound healing; reduced re-epithelialisation and collagen deposition; increased inflammation; augmented neutrophil infiltration in wounds
Hspg2 15530 Knockout Delayed wound healing and defective angiogenesis
Icam1 15894 Knockout Delayed wound healing
Icos 54167 Knockout Delayed wound healing, especially at early times; suppressed keratinocyte migration, angiogenesis and granulation tissue formation; diminished T-cell, macrophage and neutrophil infiltration; Marked suppression of cytokine expression in wounds, especially the Th2 cytokines interleukin (IL)-4; IL-6; and IL-10
Icosl 50723 Knockout Delayed wound healing, especially at early times; suppressed keratinocyte migration, angiogenesis and granulation tissue formation; diminished T-cell, macrophage and neutrophil infiltration; Marked suppression of cytokine expression in wounds, especially the Th2 cytokines interleukin (IL)-4; IL-6; and IL-10
Ido1 15930 Knockout; inhibitor administration Accelerated wound healing; Inhibitor administration accelerated wound healing in WT mice
Ifng 15978 Knockout Accelerated wound healing; rapid granulation tissue formation; enhanced angiogenesis
Igf1 16000 Overexpression Accelerated wound healing; increased proliferation and migration of keratinocytes
Il10 16153 Knockout Accelerated wound healing; accelerated re-epithelialization and enhanced contraction of the wound tissue
Il15 16168 Overexpression Accelerated wound healing
Il1r1 16177 Knockout Improved restoration of normal skin architecture with lower levels of collagen in wounds
Il1rn 16181 Knockout Attenuated collagen deposition and delayed neovascularization; exaggerated neutrophil recruitment with augmented expression of IL-1s, TNF-alpha, and CXC chemokines (MIP-2 and KC)
Il22 50929 Knockout Defects in the dermal compartment after wounding
Il33 77125 Protein administration Accelerated wound healing with enhanced re-epithelialization
Il4 16189 Double Knockout Poor scar histology and increased inflammation
Il5 16191 Knockout; overexpression IL-5 overexpression vs. knockout: delayed wound healing with impaired re-epithelialization; delay in collagen deposition; increase in inflammatory cell infiltration; altered inflammatory response
Il6 16193 Knockout Delayed wound healing; minimal epithelial bridge formation; decreased inflammation, and granulation tissue formation
Il6ra 16194 Knockout; antibody treatment Attenuates the delayed wound healing phenotype of IL6 knockout
Ilk 621824 Knockout Delayed wound closure; decrease in cellular proliferation and loss of HGF protein expression
Inhba 16323 Overexpression Enhanced granulation tissue formation; premature induction of fibronectin and tenascin-C; thickening of the epidermis; increased spinous cell layer; disorganized epidermal architecture
Itch 16396 Knockout Accelerated wound healing with a delay in epithelial remodeling
Itga11 319480 Knockout Reduced granulation tissue formation and impaired wound contraction; dermal fibroblasts are unable to efficiently convert to myofibroblasts, resulting in scar tissue with compromised tensile strength
Itga3 16400 Knockout Impaired wound healing
Itga9 104099 Knockout Thinner migrating epithelium; reduction in the number of proliferating epidermal keratinocytes
Itgam 16409 Knockout Delayed wound healing
Itgb1 16412 Knockout Impaired wound healing
Itgb2 16414 Knockout Impaired wound healing
Itgb3 16416 Knockout Accelerated wound healing and re-epithelialization
Itgb6 16420 Knockout Delayed wound healing; the most significant delay was observed at the stages where granulation tissue deposition was occurring
Jun 16476 Knockout Defects in epidermal wound healing
Junb 16477 Knockout Delayed tissue remodelling; pronounced epidermal hyperproliferation after treatment with the phorbol ester 12-O-decanoyl-phorbol-13-acetate; disturbed differentiation; prolonged inflammation
Kit 16590 Antibody treatment Reduced mast cell accumulation at the edge of healing wounds
Kl 16591 Knockout Delayed wound closure; reduced collagen deposition in the wounds; Phenotypic similarities with aged skin
Klf10 21847 Knockout Lower wound breaking strength
Klf10 21847 Knockout Delay in wound closure; impaired wound contraction, granulation tissue formation, collagen synthesis, and reepithelialization
Klf4 16600 Knockout Delayed wound healing; decreased accumulation of Myeloid-derived suppressor cells and fibrocytes
Klf4 16600 Knockout Delayed wound healing; decreased stem cell-enriched population
Klk8 259277 Knockout Delayed wound healing; defective keratinocyte proliferation, differentiation, and migration in the early stages of wound healing
Krt6a 16687 Knockout Delay in re-epithelialization only from the hair follicle; healing of wounds was not impaired
Krt76 77055 Knockout Impaired wound healing; neonatal skin flaking; hyperpigmentation, inflammation, and death prior to 12 weeks of age
Lep 16846 Knockout; protein administration; antibody treatment Knockout: Delayed wound healing; mild diabetic phenotype; systemically and topically supplemented leptin improved re-epithelialization of wounds in knockout mice; topically supplemented leptin accelerated normal wound-healing
Lgals1 16852 Knockout Delayed wound healing
Lgals3bp 19039 Knockout Delayed wound healing; reduced collagen expression
Lgals7 16858 Knockout Reduced reepithelialization potential; defect in cell migration
Lpp 210126 Knockout Reduced embryonic fibroblast migration
Lsp1 16985 Knockout Accelerated wound healing and re-epithelialization; increased collagen synthesis and angiogenesis
Lum 17022 Knockout Delayed wound healing; increase in inflammatory macrophages; delayed response of the expression of TGF-β1, type I collagen α1 and fibronectin
Map3k1 26401 siRNA knockdown Delayed wound closure; impaired activation of Jun NH2-terminal kinases, induction of plasminogen activator inhibitor (PAI)-1, and restoration of cell-cell junctions of the wounded epidermis
Map3k5 675366 Knockout Retardation of wounding-induced hair regrowth
Map3k7 666611 Knockout Impaired wound healing; decreased collagen deposition, α-SMA and CCN2 expression
Mapkapk2 17164 Knockout Higher level of acanthosis of the migrating wound keratinocyte layer; higher level of collagen deposition in the granulation tissue
Med1 19014 Knockout Accelerated wound closure and re-epithelialization
Met 17295 Knockout Keratinocytes were unable to contribute to re-epithelialization; wound closure was slightly attenuated, but occurred exclusively by a few (5%) keratinocytes that had escaped recombination
Mfap2 17150 Knockout Altered wound healing response
Mfge8 17304 Knockout Delayed wound healing; reduced myofibroblast and vessel numbers
Mgat5 107895 Overexpression Accelerated wound healing
Mif 100040259 Knockout Delayed wound healing
Mir155 387173 Knockout Accelerated wound closure; elevated numbers of macrophages
Mir21a 387140 Overexpression; antagonist andministration Overexpression of miR-21: stronger wound contraction; antagomiR administration: delay of wound closure with impaired collagen deposition
Mmp13 17386 Knockout Delayed wound healing
Mmp1a 83995 Mutation Delayed wound healing (in mice expressing the human gene in the epidermis)
Mmp3 17392 Knockout Wounds failed to contract and healed more slowly
Mmp8 17394 Knockout Impaired wound healing
Mmp9 17395 Knockout Delayed wound healing; defect in keratinocyte migration
Mrc2 17534 Knockout Delayed re-epithelialization; altered stiffness of the scar tissue; no difference in total collagen content of the wounds
Mstn 17700 Knockout Delayed wound healing; delayed epidermal reepithelialization and dermal contraction
Msx2 17702 Knockout Accelerated wound closure and re-epithelialization; earlier appearance of keratin markers for differentiation and an increased level of smooth muscle actin and tenascin in the granulation tissue
Myb 17863 Knockout Heterozygous c-myb deficiency has a functional effect on wound repair; collagen type I levels and transforming growth factor-beta1 expression are elevated
Myc 17869 Knockout Impaired wound healing
Myd88 17874 Knockout Delayed wound healing; delayed contraction; decreased and delayed granulation tissue formation; reduced new blood vessel density
Ncoa3 17979 Knockout Delayed wound healing
Ncoa6 56406 Knockout Spontaneous natural wounds healing defects
Nf1 18015 Knockout Abnormal pattern and amount of collagen-rich granulation bed tissue; skin wound fibroblasts proliferated past the normal wound maturation phase
Nfe2l2 18024 Knockout Prolonged inflammation in the late phase of repair; reduced expression of various key players in the early phase;
Nfic 18029 Knockout Accelerated wound closure; faster inflammatory stage; increased expression of PDGFA and PDGF-receptor alpha; reduced differentiation of fibroblasts to myofibroblasts
Nid1 18073 Knockout hyperproliferation of the newly formed epidermis with a delay in differentiation at day 10 post injury; considerable alpha-smooth muscle actin staining in the dermis of wounds
Nlrp3 216799 Knockout Delayed re-epithelialization, granulation tissue formation, and angiogenesis
Nos1 18125 Knockout Delayed wound closure
Nos2 18126 Knockout Delayed wound closure
Nos3 18127 Knockout Delayed wound closure
Npy2r 18167 Knockout Delayed wound closure with reduced neovascularization
Nr3c1 14815 Mutation Enlarged granulation tissue with a high fibroblast density; late wounds appeared normal; enhanced ability of fibroblasts to contract collagen
Nr3c1 14815 Overexpression Delayed wound healing; delayed re-epithelialization and formation of granulation tissue; reduced recruitment of granulocytes and macrophages; TGF-β1 and Kgf expression was repressed whereas TGF-β3 was up-regulated
Nr4a1 15370 Knockout; overexpression Delayed wound healing in a dominant negative mutant
Ogfr 72075 Overexpression Delayed wound healing
Oprd1 18386 Knockout Delayed wound healing; severe epidermal hypertrophy at the wound margin
P2ry2 18442 Knockout Increased wound size at day 14 post-wounding; reduction in the expression of Ki67, VEGF, collagen I, fibronectin and α-SMA
Panx1 55991 Knockout Delayed wound healing
Pear1 73182 Knockout Accelerated wound closure
Perp 64058 Knockout Delayed wound healing
Pgf 18654 Knockout Impaired angiogenesis, plasma extravasation and collateral growth
Pik3cg 30955 Mutation Delayed resolution of inflammation in wound healing; increased proliferation and decreased apoptosis
Pkd1 18763 Knockout Delayed wound re-epithelialization; reduced proliferation and migration of keratinocytes at the wound edge
Plaur 18793 Knockout Delayed wound healing
Plec 18810 Knockout Reduced leukocyte infiltration
Plg 18815 Knockout Impaired wound healing
Postn 50706 Knockout Delayed wound healing (rescued by direct administration of exogenous periostin)
Pou2f3 18988 Knockout Various effects on differentiation of epidermal keratinocytes during normal development and wound healing
Pou3f1 18991 Knockout Various effects on differentiation of epidermal keratinocytes during normal development and wound healing
Ppara 19013 Mutation Modulation of early inflammation phase
Ppard 19015 Mutation Impaired adhesion and migration properties
Pparg 19016 Knockout Impaired wound healing with reduced collagen deposition, angiogenesis and granulation formation
Ppp1r15a 17872 Knockout Accelerated wound healing; reduced amounts of myosin IIA in migrating macrophages and myofibroblasts
Prdx6 11758 Knockout Damaged endothelial cells with an enhanced rate of apoptosis; hemorrhage in the granulation tissue
Prkca 18750 Knockout Delayed granulation tissue deposition; failure to upregulate collagen and other ECM components
Prkce 18754 Knockout Delayed wound closure and a reduction in myofibroblasts
Prkch 18755 Knockout Delayed wound healing, particularly re-epithelialization
Pten 19211 Knockout Various effects indicating the importance of mTOR
Ptger3 19218 Knockout Delayed wound closure and re-epithelization; inhibited angiogenesis; reduction in immunoreactive vascular endothelial growth factor (VEGF) in granulation tissues
Ptgs1 19224 Knockout Reduced breaking strength; enhanced angiogenesis; reduced macrophages and myofibroblasts at day 12
Ptgs2 19225 Knockout Reduced breaking strength; enhanced angiogenesis; reduced macrophages and myofibroblasts at day 12
Ptk2 14083 Knockout Delayed wound healing; decreased dermal thickness and collagen density
Ptk2b 19229 Knockout Delayed wound closure
Ptk7 71461 Knockout Defective wound repair
Rac1 19353 Knockout Delayed wound closure; reduced collagen production and myofibroblast formation
Rac2 19354 Knockout Reduced wound-related lipid peroxidation
Raf1 110157 Knockout Delayed wound healing
Ramp1 51801 Knockout Suppressed wound healing and wound-induced angiogenesis; reduced expression of vascular endothelial growth factor (VEGF)-A
Reck 631094 Knockout Improved wound healing
Ripk3 56532 Knockout Delayed wound healing
S100a9 20202 Knockout Diminished recruitment of granulocytes into the granulation tissue
Scrib 105782 Knockout Defective wound repair
Sdc1 20969 Knockout Prolonged hypoplasia; delayed cell proliferation and reduced localization of alpha9 integrin in the epidermis
Sdc4 20971 Knockout Delayed wound healing and impaired angiogenesis in the granulation tissue
Sele 20339 Double Knockout Reduced recruitment of inflammatory cells and impaired wound closure in mice deficient in both P- and E-selectins
Sell 20343 Knockout Delayed wound healing
Selp 20344 Double Knockout Reduced recruitment of inflammatory cells and impaired wound closure in mice deficient in both P- and E-selectins
Sept4 18952 Knockout Improvement in wound healing and regeneration of hair follicles
Serpine1 18787 Knockout Accelerated wound closure
Serpinf2 18816 Knockout Accelerated wound closure; increased angiogenesis
Sfpi1 20375 Knockout Accelerated wound healing with reduced fibrosis; incapacity to raise the standard inflammatory response, due to a lack of macrophages and functioning neutrophils
Siah2 20439 Knockout Delayed wound healing; delayed induction of myofibroblast infiltration and reduced collagen deposition; delayed angiogenesis and reduced macrophage infiltration into the wounds
Slc11a1 18173 Knockout Delayed wound healing
Slc6a6 21366 Knockout Delayed wound closure in 12-mo mice; no effect in 5-mo mice
Slpi 20568 Knockout Impaired wound healing with increased inflammation and elastase activity
Smad2 17126 Overexpression Delayed wound healing; a defect in basal keratinocyte migration
Smad3 17127 Knockout Accelerated dorsal wound healing; ear wounds are enlarged resulting from changes in extracellular matrix molecules
Smad4 17128 Knockout Delayed wound closure and remodeling; increased angiogenesis and inflammation
Smad7 17131 Overexpression Accelerated re-epithelialization; increase in keratinocyte proliferation; reduced Smad2 activation; increased activation of extracellular signal-regulated kinase (Erk)
Snai2 20583 Knockout Reduced re-epithelialization; increased expression of the Slug target genes keratin 8 and E-cadherin at wound margins; 40% of mice developed non-healing cutaneous ulcers in response to chronic UVR
Socs3 12702 Overexpression Impaired wound healing; atrophied wound-margin epithelia and augmented response of keratinocytes; a prolonged persistence of neutrophils and macrophages; elevated levels of TGF-beta1
Sod1 545845 Knockout Delayed wound healing
Sorbs3 20410 Knockout Delay in wound healing in both back and tail, without affecting the proliferation of keratinocytes
Sparc 100046740 Knockout Accelerated wound closure
Sparcl1 13602 Knockout Accelerated wound healing; enhanced macrophage infiltration of wound beds at early time points; earlier appearance of mature extracellular matrix; fibrovascular invasion of polyvinyl alcohol sponges was more robust
Spi1 20375 knockout Scar-free repair; altered growth factor and cytokine profile; cell death is reduced, and dying cells are instead engulfed by stand-in phagocytic fibroblasts
Spp1 20750 Knockout Decreased level of debridement; greater disorganization of matrix; alteration of collagen fibrillogenesis leading to small diameter collagen fibrils; tensile properties of the wounds were unchanged
Stat3 20848 Knockout Compromised wound healing and hair cycle; developed spontaneously occurring ulcers with age
Tcf3 21423 Overexpression Accelerated wound healing and keratinocyte migration
Tert 21752 Overexpression Accelerated wound healing
Tgfa 21802 Knockout Ear model: delayed re-epithelialization; Head model: no difference in epithelial gap or new granulation tissue
Tgfb1 21803 Knockout Decreased granulation tissue formation, vascularity, collagen deposition, epithelialization and a marked inflammatory infiltrate
Tgfb3 21809 Protein administration Scar-free wound healing in adults
Tgfbr2 21813 Knockout Accelerated wound closure and re-epithelization; reduced collagen deposition and remodeling; reduced extent of wound contraction, and elevated macrophage infiltration
Tgm1 21816 Knockout Delayed wound healing
Thbd 21824 Overexpression Delayed wound healing; reduced granulation tissue formation and highly diminished wound angiogenesis
Thbd 21824 Knockout Delayed wound healing
Thbs1 21825 Overexpression Delayed wound healing; reduced granulation tissue formation and highly diminished wound angiogenesis
Thbs2 21826 Knockout Improved wound healing
Thra 100047427 Knockout Delayed re-epithelialization and wound closure; impaired keratinocyte proliferation
Thrb 21834 Knockout Delayed re-epithelialization and wound closure; impaired keratinocyte proliferation
Thy1 21838 siRNA treatment Impaired wound healing; the level of TGF-β1 at the wound continuously increased
Timp1 21857 Knockout Delayed wound healing with slow migration of keratinocytes over the wound
Tlr2 24088 Knockout Delayed wound healing; decreased numbers of infiltrating macrophages in the dermis and decreased TGF-β and CCL5 mRNA expression
Tlr4 21898 Knockout Delayed wound healing; decreased numbers of infiltrating macrophages in the dermis and decreased TGF-β and CCL5 mRNA expression
Tlr9 81897 Knockout Delayed wound healing
Tnf 21926 Knockout Promotion of granulation tissue formation and delayed re-epithelialization
Tnfrsf1a 21937 Knockout Accelerated wound healing; enhanced angiogenesis and collagen content; accelerated re-epithelialization with increased gene expression of TGF-beta1, CTGF, VEGF, Flt-1, and Flk-1
Tnfsf14 50930 Knockout Impaired wound healing with characteristics of nonchronic and chronic ulcers
Tnxb 81877 Knockout Reduced breaking strength of unwounded skin; after wounding, scars do not progress beyond the mechanical strength of uninjured skin; no obvious differences in the rate of wound closure
Tpm3 236479 Deletion of exon Accelerated wound healing; increased cell migration
Trp53 22059 Mutation Delayed wound closure
Trpc6 22068 Knockout Impaired wound healing
Tsc1 64930 Knockout Accelerated wound healing
Tsk2 109631 Knockout Delayed wound healing
Vangl2 93840 Knockout; Double Knockout Defective wound repair
Vav1 22324 Knockout Delayed wound healing
Vav3 57257 Knockout Delayed wound healing
Vegfa 22339 Overexpression; inhibitor administration Promotion of lymphangiogenesis; systemic blockade of VEGFR-2 prevented lymphatic vessel formation
Vegfa 22339 Overexpression Rapid wound closure
Vegfa 22339 Protein administration Improved wound healing by locally up-regulating growth factors important for tissue repair and by systemically mobilizing bone marrow-derived cells
Vim 22352 Knockout Delayed wound contraction, migration of fibroblasts into the wound site, and appearance of myofibroblasts at the wound site
Vtn 22370 Knockout Delayed wound healing; extensive areas of delayed hemorrhage near the sprouting tips of microvessels between days 7 and 14
Wfdc1 67866 Knockout Accelerated wound closure; elevated deposition of osteopontin and macrophage recruitment
Contact: Vadim E. Fraifeld, MD, PhD
Head: Lab for the Biology of Aging, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev
P.O. Box 653, Beer-Sheva 8410501, Israel
Email:
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Yanai H, Budovsky A, Tacutu R, Barzilay T, Abramovich A, Ziesche R, Fraifeld VE. Tissue repair genes: the TiRe database and its implication for skin wound healing. Oncotarget. 2016; 7:21145-55.