Knockout; antibody treatment of Flii in Mus musculus


Gene symbol Flii
Gene name Flightless I Homolog (Drosophila); Similar To Cytoskeletal Actin-Modulating Protein
Gene entrez ID 100044937
Gene aliases FLI, FLIL, Fli1, MGC39265
Organism House mouse, Mus musculus (@AnAge)
Interactions Protein-protein interaction partners (@BioGRID)


Gene symbol FLII
HUGO gene ID 3750
Gene entrez ID 2314
Genecards FLII


Intervention Knockout; antibody treatment
Genetic background BALB/c
Wound model Burn Wound
Wound Dimensions 29 mm^2
Wound Location Dorsum
Effect on skin wound healing Intradermal injection of Flii-neutralizing antibodies to burn wounds improved their healing; Knockout: TGF-beta1 protein and gene expression were reduced while aTGF-beta3 was elevated; decreased anti-α-SMA
References Adams et al. 2009

Contact: Vadim E. Fraifeld, MD, PhD
Head: Lab for the Biology of Aging, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev
P.O. Box 653, Beer-Sheva 8410501, Israel
Email:
How to cite us:
If you would like to cite this database please use:
Yanai H, Budovsky A, Tacutu R, Barzilay T, Abramovich A, Ziesche R, Fraifeld VE. Tissue repair genes: the TiRe database and its implication for skin wound healing. Oncotarget. 2016; 7:21145-55.