Knockout of Icos in Mus musculus


Gene symbol Icos
Gene name Inducible T-Cell Co-Stimulator; Similar To Activation-Inducible Lymphocyte Immunomediatory Molecule Ailim
Gene entrez ID 54167
Gene aliases AILIM, CD278
Organism House mouse, Mus musculus (@AnAge)
Interactions Protein-protein interaction partners (@BioGRID)


Gene symbol ICOS
HUGO gene ID 5351
Gene entrez ID 29851
Genecards ICOS


Intervention Knockout
Genetic background C57BL/6
Wound model Full-Thickness Excisional Punch
Wound Dimensions 6 mm ⌀
Wound Location Dorsum
Effect on skin wound healing Delayed wound healing, especially at early times; suppressed keratinocyte migration, angiogenesis and granulation tissue formation; diminished T-cell, macrophage and neutrophil infiltration; Marked suppression of cytokine expression in wounds, especially the Th2 cytokines interleukin (IL)-4; IL-6; and IL-10
References Maeda et al. 2011

Contact: Vadim E. Fraifeld, MD, PhD
Head: Lab for the Biology of Aging, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev
P.O. Box 653, Beer-Sheva 8410501, Israel
Email:
How to cite us:
If you would like to cite this database please use:
Yanai H, Budovsky A, Tacutu R, Barzilay T, Abramovich A, Ziesche R, Fraifeld VE. Tissue repair genes: the TiRe database and its implication for skin wound healing. Oncotarget. 2016; 7:21145-55.