Knockout of Icosl in Mus musculus


Gene symbol Icosl
Gene name Icos Ligand
Gene entrez ID 50723
Gene aliases KIAA0653, GL50, B7-H2, B7RP-1, B7H2, B7RP1, ICOS-L, CD275
Organism House mouse, Mus musculus (@AnAge)
Interactions Protein-protein interaction partners (@BioGRID)


Gene symbol ICOSLG
HUGO gene ID 17087
Gene entrez ID 23308
Genecards ICOSLG


Intervention Knockout
Genetic background C57BL/6
Wound model Full-Thickness Excisional Punch
Wound Dimensions 6 mm ⌀
Wound Location Dorsum
Effect on skin wound healing Delayed wound healing, especially at early times; suppressed keratinocyte migration, angiogenesis and granulation tissue formation; diminished T-cell, macrophage and neutrophil infiltration; Marked suppression of cytokine expression in wounds, especially the Th2 cytokines interleukin (IL)-4; IL-6; and IL-10
References Maeda et al. 2011

Contact: Vadim E. Fraifeld, MD, PhD
Head: Lab for the Biology of Aging, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev
P.O. Box 653, Beer-Sheva 8410501, Israel
Email:
How to cite us:
If you would like to cite this database please use:
Yanai H, Budovsky A, Tacutu R, Barzilay T, Abramovich A, Ziesche R, Fraifeld VE. Tissue repair genes: the TiRe database and its implication for skin wound healing. Oncotarget. 2016; 7:21145-55.