Knockout of Akt1 in Mus musculus


Gene symbol Akt1
Gene name Thymoma Viral Proto-Oncogene 1; Similar To Serine/Threonine Protein Kinase
Gene entrez ID 100047666
Gene aliases RAC, PKB, PRKBA, AKT
Organism House mouse, Mus musculus (@AnAge)
Interactions Protein-protein interaction partners (@BioGRID)


Gene symbol AKT1
HUGO gene ID 391
Gene entrez ID 207
Genecards AKT1


Intervention Knockout
Genetic background 129 R1/C57BL/6
Wound model Full-Thickness Incision
Wound Dimensions 15 mm
Wound Location Dorsum
Effect on skin wound healing Impaired assembly of collagen in skin wounds and around the blood vessels; reduced vascular area and impaired vascular maturation; lower expression of VEGF; no significant difference in migration of fibroblasts into the wound area was observed and the dynamics of wound closure were similar
References Somanath et al. 2008
Bancroft et al. 2015

Contact: Vadim E. Fraifeld, MD, PhD
Head: Lab for the Biology of Aging, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev
P.O. Box 653, Beer-Sheva 8410501, Israel
Email:
How to cite us:
If you would like to cite this database please use:
Yanai H, Budovsky A, Tacutu R, Barzilay T, Abramovich A, Ziesche R, Fraifeld VE. Tissue repair genes: the TiRe database and its implication for skin wound healing. Oncotarget. 2016; 7:21145-55.