| Intervention | Knockout |
| Genetic background | C57BL/6J:N |
| Wound model | Full-Thickness Excisional Punch |
| Wound Dimensions | 5 mm â |
| Wound Location | Dorsum |
| Effect on skin wound healing | Impaired wound healing; neonatal skin flaking; hyperpigmentation, inflammation, and death prior to 12 weeks of age |
| References | DiTommaso et al. 2014 |