Knockout; protein administration; antibody treatment of Lep in Mus musculus


Gene symbol Lep
Gene name Leptin
Gene entrez ID 16846
Gene aliases 0
Organism House mouse, Mus musculus (@AnAge)
Interactions Protein-protein interaction partners (@BioGRID)


Gene symbol LEP
HUGO gene ID 6553
Gene entrez ID 3952
Genecards LEP


Intervention Knockout; protein administration; antibody treatment
Genetic background C57BL/6J
Wound model Full-Thickness Excisional Punch
Wound Dimensions N/A
Wound Location Dorsum
Effect on skin wound healing Knockout: Delayed wound healing; mild diabetic phenotype; systemically and topically supplemented leptin improved re-epithelialization of wounds in knockout mice; topically supplemented leptin accelerated normal wound-healing
References Frank et al. 2000
Murad et al. 2003
Tadokoro et al. 2015

Contact: Vadim E. Fraifeld, MD, PhD
Head: Lab for the Biology of Aging, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev
P.O. Box 653, Beer-Sheva 8410501, Israel
Email:
How to cite us:
If you would like to cite this database please use:
Yanai H, Budovsky A, Tacutu R, Barzilay T, Abramovich A, Ziesche R, Fraifeld VE. Tissue repair genes: the TiRe database and its implication for skin wound healing. Oncotarget. 2016; 7:21145-55.