Knockout of Bcl11b in Mus musculus


Gene symbol Bcl11b
Gene name B-Cell Leukemia/Lymphoma 11B
Gene entrez ID 58208
Gene aliases CTIP-2, CTIP2, hRIT1-alpha
Organism House mouse, Mus musculus (@AnAge)
Interactions Protein-protein interaction partners (@BioGRID)


Gene symbol BCL11B
HUGO gene ID 13222
Gene entrez ID 64919
Genecards BCL11B


Intervention Knockout
Genetic background C57BL/6
Wound model Full-Thickness Excisional Punch
Wound Dimensions 5 mm ⌀
Wound Location Dorsum
Effect on skin wound healing Defects in proliferation and migration of keratinocytes during re-epithelialization; Reduced epidermal proliferation; delayed keratinocyte activation; altered cell-cell adhesion and impaired ECM development; Post wounding: lack of E-Cadherin suppression in the migratory tongue; insufficient expression of alpha smooth muscle actin (α-SMA) in the dermis; robust induction of K8; dysregulated expression of several hair follicle (HF) stem cell markers
References Liang et al. 2012

Contact: Vadim E. Fraifeld, MD, PhD
Head: Lab for the Biology of Aging, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev
P.O. Box 653, Beer-Sheva 8410501, Israel
Email:
How to cite us:
If you would like to cite this database please use:
Yanai H, Budovsky A, Tacutu R, Barzilay T, Abramovich A, Ziesche R, Fraifeld VE. Tissue repair genes: the TiRe database and its implication for skin wound healing. Oncotarget. 2016; 7:21145-55.