Antibody treatment, protein administration of Tgfb2 in Rattus norvegicus


Gene symbol Tgfb2
Gene name Transforming Growth Factor, Beta 2
Gene entrez ID 81809
Gene aliases 0
Organism Norway rat, Rattus norvegicus (@AnAge)
Interactions Protein-protein interaction partners (@BioGRID)


Gene symbol TGFB2
HUGO gene ID 11768
Gene entrez ID 7042
Genecards TGFB2


Intervention Antibody treatment, protein administration
Genetic background Sprague-Dawley
Wound model Full-Thickness Incision
Wound Dimensions 1 cm^2
Wound Location Dorsum
Effect on skin wound healing Neutralising TGF-beta 2 alone had no effect; combined with TGF-beta 1, it reduced the monocyte and macrophage profile, neovascularisation, fibronectin, collagen III and collagen I deposition in the early stages of wound healing; markedly improved the architecture of the neodermis to resemble that of normal dermis and reduced scarring; by contrast, wounds treated with either TGF-beta 1 or with TGF-beta 2 had more extracellular matrix deposition in the early stages of wound healing but did not differ from control wounds in the final quality of scarring
References Shah et al. 1995

Contact: Vadim E. Fraifeld, MD, PhD
Head: Lab for the Biology of Aging, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev
P.O. Box 653, Beer-Sheva 8410501, Israel
Email:
How to cite us:
If you would like to cite this database please use:
Yanai H, Budovsky A, Tacutu R, Barzilay T, Abramovich A, Ziesche R, Fraifeld VE. Tissue repair genes: the TiRe database and its implication for skin wound healing. Oncotarget. 2016; 7:21145-55.