| Intervention | Overexpression (intramuscular gene transfer) |
| Genetic background | N/A |
| Wound model | Clinical trial (Buerger's disease) |
| Wound Dimensions | N/A |
| Wound Location | N/A |
| Effect on skin wound healing | Nonhealing ulcers healed better; improved blood flow with newly visible collateral vessels; adverse consequences were limited to transient ankle or calf edema |
| References | Isner et al. 1998 |