Knockout; antagonist administration of Calca in Mus musculus


Gene symbol Calca
Gene name Calcitonin/Calcitonin-Related Polypeptide, Alpha
Gene entrez ID 12310
Gene aliases FLJ30166, CGRP-II
Organism House mouse, Mus musculus (@AnAge)
Interactions Protein-protein interaction partners (@BioGRID)


Gene symbol CALCB
HUGO gene ID 1438
Gene entrez ID 797
Genecards CALCB


Intervention Knockout; antagonist administration
Genetic background C57BL/6
Wound model Full-Thickness Excisional Punch
Wound Dimensions 8 mm ⌀
Wound Location Dorsum
Effect on skin wound healing Suppressed angiogenesis and wound closure; reduction in expressions of vascular endothelial growth factor (VEGF) in the wound granulation tissues; Antagonist administration (when infused with mini-osmotic pumps) subcutaneously blocked the wound healing processes and reduced the expressions of CD31 and VEGF expression in the wound granulation tissues
References Toda et al. 2008

Contact: Vadim E. Fraifeld, MD, PhD
Head: Lab for the Biology of Aging, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev
P.O. Box 653, Beer-Sheva 8410501, Israel
Email:
How to cite us:
If you would like to cite this database please use:
Yanai H, Budovsky A, Tacutu R, Barzilay T, Abramovich A, Ziesche R, Fraifeld VE. Tissue repair genes: the TiRe database and its implication for skin wound healing. Oncotarget. 2016; 7:21145-55.