Overexpression of Cast in Mus musculus


Gene symbol Cast
Gene name Calpastatin
Gene entrez ID 12380
Gene aliases 0
Organism House mouse, Mus musculus (@AnAge)
Interactions Protein-protein interaction partners (@BioGRID)


Gene symbol CAST
HUGO gene ID 1515
Gene entrez ID 831
Genecards CAST


Intervention Overexpression
Genetic background C57BL/6
Wound model Full-Thickness Excisional Punch
Wound Dimensions 5 mm ⌀
Wound Location Dorsum
Effect on skin wound healing Delay in wound healing, particularly in the initial steps; reduced proliferation in the epidermis and delayed re-epithelization; impaired granulation tissue formation; reduction in CD45+ leukocyte infiltrate and in CD31+ blood vessel density; reduction in α-SMA expressing myofibroblasts
References Nassar et al. 2012

Contact: Vadim E. Fraifeld, MD, PhD
Head: Lab for the Biology of Aging, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev
P.O. Box 653, Beer-Sheva 8410501, Israel
Email:
How to cite us:
If you would like to cite this database please use:
Yanai H, Budovsky A, Tacutu R, Barzilay T, Abramovich A, Ziesche R, Fraifeld VE. Tissue repair genes: the TiRe database and its implication for skin wound healing. Oncotarget. 2016; 7:21145-55.