Intervention | Overexpression |
Genetic background | FVB |
Wound model | Flap with centrally located excisional wounds |
Wound Dimensions | 4 mm |
Wound Location | Dorsum |
Effect on skin wound healing | Hypoxic wounds in both transgenic and wild-type mice increased levels of HIF-1α and delayed wound closure; Hypoxic wounds in transgenic mice decreased collagen type 1 and fibronectin expression and reduced dermal thickness on day 7 post-wounding |
References | Vorstenbosch et al. 2013 Winocour et al. 2014 |